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Tbio
RCN1
Reticulocalbin-1

Protein Summary
Description
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000054950
  • ENSP00000054950
  • ENSG00000049449

Symbol
  • RCN
  • RCN
  • RCAL
  • PIG20
  • HEL-S-84
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
protein complex
0.97
PubMedID
0.92
transcription factor perturbation
0.91
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.38   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.38   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0