Property Summary

NCBI Gene PubMed Count 13
PubMed Score 103.77
PubTator Score 320.53

Knowledge Summary


No data available


  Differential Expression (25)

Disease log2 FC p
malignant mesothelioma -5.200 1.4e-09
astrocytic glioma -3.100 5.5e-03
ependymoma -4.800 1.0e-03
oligodendroglioma -2.600 1.6e-02
psoriasis -1.800 3.2e-07
glioblastoma -3.000 1.7e-06
sonic hedgehog group medulloblastoma -3.700 1.7e-09
cystic fibrosis -1.031 3.3e-04
atypical teratoid / rhabdoid tumor -4.600 1.6e-09
medulloblastoma, large-cell -4.100 7.0e-05
primitive neuroectodermal tumor -2.600 6.8e-03
non-small cell lung cancer -1.588 1.2e-13
intraductal papillary-mucinous adenoma (... -3.100 1.0e-04
intraductal papillary-mucinous carcinoma... -3.000 1.5e-03
intraductal papillary-mucinous neoplasm ... -3.200 1.5e-03
colon cancer -3.100 5.5e-03
lung cancer -1.900 1.1e-03
adult high grade glioma -3.200 3.6e-05
pilocytic astrocytoma -2.400 6.7e-07
severe Alzheimer's disease -1.158 3.5e-02
lung carcinoma 1.900 7.4e-16
Pick disease -1.600 7.0e-03
invasive ductal carcinoma -2.200 3.1e-03
pituitary cancer 1.900 3.6e-08
head and neck cancer -1.700 1.6e-02


Accession Q14206 A6ND07 B3KR46 Q5VWF7 Q5VWF8 Q8N116
Symbols CSP2


PANTHER Protein Class (1)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG Inparanoid

 GWAS Trait (1)

Gene RIF (4)

20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19819266 our data have elucidated the molecular and cellular mechanism whereby PGF(2alpha) regulates CXCL8 expression via the FP receptor in endometrial adenocarcinomas and have highlighted RCAN1-4 as a negative regulator of CXCL8 expression
17610901 DSCR1-L1 is constitutively expressed in endothelial cells and acts similar to DSCR1 in inhibiting calcineurin activity and restraining VEGF-mediated angiogenesis.
12102656 the expression of ZAKI-4 isoforms is subjected to distinct hormonal as well as tissue-specific regulation, constituting a complex signalling network through inhibition of calcineurin.

AA Sequence


Text Mined References (14)

PMID Year Title
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19819266 2009 Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway.
17610901 2007 Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12102656 2002 Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors.
10861295 2000 DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.
10756093 2000 A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).
10722714 2000 A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8662924 1996 Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts.