Tbio RBFOX3 RNA binding protein fox-1 homolog 3

Protein Summary

Description

Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• A6NFN3
• B4DEG6
• B4DF29

Gene Name

• RBFOX3

Ensembl ID

• ENST00000580155
• ENSP00000463653
• ENSG00000167281
• ENST00000584778
• ENSP00000462007

Symbol

• FOX3
• NEUN
• FOX-3
• HRNBP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
disease	0.68
cell type or tissue	0.63
cell line	0.58
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Binding Protein Fox-1 Homolog 3

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Binding Protein Fox-1 Homolog 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3042.33   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 355   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3042.33   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0