RASSF8
Ras association domain-containing protein 8
Protein Summary
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
- ENST00000282884
- ENSP00000282884
- ENSG00000123094
- ENST00000381352
- ENSP00000370756
- ENST00000405154
- ENSP00000384491
- ENST00000541490
- ENSP00000443096
- ENST00000542865
- ENSP00000439839
- ENST00000615708
- ENSP00000481417
- C12orf2
- HOJ1
- C12orf2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
microRNA | 0.94 | ||
virus perturbation | 0.79 | ||
transcription factor | 0.69 | ||
small molecule perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.35 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 326 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.35 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 326 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0