Property Summary

NCBI Gene PubMed Count 15
PubMed Score 0.00
PubTator Score 7.28

Knowledge Summary


No data available


  Differential Expression (18)

Disease log2 FC p
gastric cancer 1.300 5.9e-03
pancreatic cancer 1.100 1.9e-02
astrocytic glioma -2.000 1.4e-02
ependymoma -2.100 2.5e-02
oligodendroglioma -1.700 3.0e-02
osteosarcoma -1.979 6.3e-04
primary pancreatic ductal adenocarcinoma 1.034 8.7e-03
non-small cell lung cancer -1.176 3.7e-16
intraductal papillary-mucinous adenoma (... 1.200 4.3e-03
intraductal papillary-mucinous neoplasm ... 1.400 1.4e-02
group 4 medulloblastoma -1.300 2.4e-02
pancreatic carcinoma 1.100 1.9e-02
subependymal giant cell astrocytoma 1.837 1.8e-02
lung adenocarcinoma -1.100 1.2e-09
lung carcinoma -2.400 4.0e-37
Pick disease 1.300 2.3e-04
ovarian cancer -2.800 1.0e-09
pituitary cancer 2.000 1.9e-04

Gene RIF (7)

24295637 Taken together, these findings indicate that the RASSF3 promoter rs6581580 T>G SNP is potentially functional, modulating susceptibility to SCCHN among non-Hispanic whites.
24246507 low expression is associated with malignant phenotypes in non-small cell lung cancer patients
23555615 hypermethylation-induced RASSF3 silencing plays an important role in the tumorigenesis of pituitary somatotroph adenomas.
22593196 tumor suppressor activity of RASSF3, which occurs through p53 stabilization and regulation of apoptosis and the cell cycle.
20237496 Observational study of gene-disease association. (HuGE Navigator)
19148488 Mammary tumor incidence in bi-transgenic mice is delayed, suggesting that transgenic Rassf3 may influence mammary tumor incidence in transgenic mice
11965544 The presence of a Ras association domain common to NORE1,RASSF1, and RASSF3 suggests their possible involvement inRas-like signaling pathways.

AA Sequence

EQLQNLKRRYTAYRQKLEEALREVWKPD                                              211 - 238

Text Mined References (16)

PMID Year Title
24366813 2013 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
24295637 2014 Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck.
24255178 2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
24246507 2014 RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer.
23555615 2013 Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomas.
23455922 2013 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
22593196 2012 The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53.
20920251 2010 Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19369195 2009 Large-scale proteomics analysis of the human kinome.
19148488 2009 Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
15569673 2005 Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11965544 2002 RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1.