Tbio RASA4 Ras GTPase-activating protein 4

Protein Summary

Description

Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43374
• O60286
• Q14CQ4
• Q86UW3
• Q96QU0

Gene Name

• RASA4

Ensembl ID

• ENST00000262940
• ENSP00000262940
• ENSG00000105808
• ENST00000449970
• ENSP00000412876

Symbol

• CAPRI
• GAPL
• KIAA0538
• GAPL
• CAPRI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
virus perturbation	0.64
tissue sample	0.63
transcription factor perturbation	0.61
PubMedID	0.53

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras Gtpase-activating Protein 4

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras Gtpase-activating Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 525.39   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 525.39   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0