Tdark | Ras GTPase-activating protein 2 |
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Comments
Disease | Target Count | P-value |
---|---|---|
juvenile dermatomyositis | 1187 | 1.1e-10 |
ulcerative colitis | 1819 | 4.9e-06 |
osteosarcoma | 7950 | 1.9e-05 |
medulloblastoma, large-cell | 6241 | 2.4e-04 |
cystic fibrosis | 1696 | 2.6e-04 |
Pick disease | 1894 | 2.9e-04 |
Duchenne muscular dystrophy | 601 | 3.8e-04 |
primitive neuroectodermal tumor | 3035 | 6.0e-04 |
psoriasis | 6694 | 7.5e-04 |
gastric carcinoma | 807 | 5.2e-03 |
pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.0e-02 |
intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.1e-02 |
pancreatic cancer | 2398 | 1.4e-02 |
Rheumatoid arthritis | 1191 | 3.9e-02 |
Gaucher disease type 1 | 180 | 3.9e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Peripheral vascular disease | 87 | 0.0 | 3.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Mutism | 17 | 3.814 | 1.9 |
Gingival fibromatosis | 14 | 3.491 | 1.7 |
Kuru | 7 | 3.371 | 1.7 |
Creutzfeldt-Jakob disease | 21 | 3.34 | 1.7 |
Variant Creutzfeldt-Jakob disease | 16 | 3.333 | 1.7 |
Fatal familial insomnia | 10 | 3.301 | 1.7 |
Coffin-Lowry syndrome | 9 | 3.268 | 1.6 |
Olfactory neuroblastoma | 4 | 3.25 | 1.6 |
LEOPARD syndrome | 20 | 3.092 | 1.5 |
Disease | Target Count |
---|---|
Noonan syndrome | 34 |
Disease | log2 FC | p |
---|---|---|
cystic fibrosis | 1.060 | 2.6e-04 |
Duchenne muscular dystrophy | 1.024 | 3.8e-04 |
gastric carcinoma | 1.100 | 5.2e-03 |
Gaucher disease type 1 | -1.300 | 3.9e-02 |
intraductal papillary-mucinous neoplasm ... | 2.000 | 1.1e-02 |
juvenile dermatomyositis | 1.536 | 1.1e-10 |
medulloblastoma, large-cell | -1.200 | 2.4e-04 |
osteosarcoma | 2.193 | 1.9e-05 |
pancreatic cancer | 1.300 | 1.4e-02 |
pancreatic ductal adenocarcinoma liver m... | 1.568 | 1.0e-02 |
Pick disease | 1.200 | 2.9e-04 |
primitive neuroectodermal tumor | 1.300 | 6.0e-04 |
psoriasis | -1.400 | 7.5e-04 |
Rheumatoid arthritis | 1.300 | 3.9e-02 |
ulcerative colitis | 1.100 | 4.9e-06 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQ 1 - 70 EEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSL 71 - 140 QPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKT 141 - 210 KVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLR 211 - 280 TDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYIL 281 - 350 SEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV 351 - 420 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMAT 421 - 490 QRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSS 491 - 560 FKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNFKKRW 561 - 630 FCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDV 631 - 700 LCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSL 701 - 770 LKLQKMEEACGTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS 771 - 840 KENPIVGKAS 841 - 850 //