Tclin RARA Retinoic acid receptor alpha

Protein Summary

Description

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• P10276
• B8Y636
• P78456
• Q13440
• Q13441
• Q96S41
• Q9NQS0
• RAR-alpha

Gene Name

• RARA

Ensembl ID

• ENST00000254066
• ENSP00000254066
• ENSG00000131759
• ENST00000394081
• ENSP00000377643
• ENST00000394089
• ENSP00000377649
• ENST00000425707
• ENSP00000389993

Symbol

• NR1B1
• RAR
• NR1B1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
molecular function	1
transcription factor	0.91
biological term	0.89

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Retinoic Acid Receptor Alpha

Protein / Receptor / Retinoic Acid Receptor Alpha

Protein / Nucleic Acid Binding / Retinoic Acid Receptor Alpha

Protein / ... / C4 Zinc Finger Nuclear Receptor / Retinoic Acid Receptor Alpha

DTO Classes

Protein / Nuclear Receptor / Retinoic Acid Receptors / Retinoic Acid Receptor Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1369.7   (req: < 5)

Gene RIFs: 229   (req: <= 3)

Antibodies: 708   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1369.7   (req: >= 5)

Gene RIFs: 229   (req: > 3)

Antibodies: 708   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 85

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8