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Tchem
RAPGEF3
Rap guanine nucleotide exchange factor 3

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389212
  • ENSP00000373864
  • ENSG00000079337
  • ENST00000395358
  • ENSP00000378764
  • ENST00000405493
  • ENSP00000384521
  • ENST00000449771
  • ENSP00000395708
  • ENST00000549151
  • ENSP00000448619

Symbol
  • CGEF1
  • EPAC
  • EPAC1
  • EPAC
  • EPAC1
  • bcm910
  • HSU79275
  • CAMP-GEFI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.98
biological term
0.89
transcription factor perturbation
0.88
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.02   (req: < 5)
Gene RIFs: 149   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.02   (req: >= 5)
Gene RIFs: 149   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0