Property Summary

NCBI Gene PubMed Count 45
PubMed Score 63.00
PubTator Score 52.87

Knowledge Summary


No data available


  Disease (2)


Gene RIF (15)

23108393 Sgk1-dependent regulation of RANBP1 has functional consequences on both mitotic microtubule activity and taxol sensitivity of cancer cells.
22190034 HIV-1 Vpu is identified to have a physical interaction with RAN binding protein 1 (RANBP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
21813642 in vitro and in vivo phosphorylation of RanBP1 by Plk1 as well as the importance of phosphorylation of RanBP1 in the interaction between Plk1 and Ran during early mitosis, is demonstrated.
21184585 RANBP1 on 22q11.21 locus might be causally related to the smooth pursuit eye movement abnormality rather than the development of schizophrenia.
20658144 Downregulation of the Ran GTPase effector RanBP1 is required for nuclear reorganisation.
20508983 Observational study of gene-disease association. (HuGE Navigator)
19549784 Generation of Ran-GTP from Ran-GDP by importin-beta is activated by Ran-binding protein-1 (RanBP1) that forms a trimeric complex with Ran-GDP and importin-beta.
19270727 RanBP1-interfered cells show an increased apoptotic response to taxol compared to their counterpart with normal or high RanBP1 levels, and this response is caspase-3 dependent.
19149558 HIV-1 Vpu is identified to have a physical interaction with RAN binding protein 1 (RANBP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
18187620 HIV-1 Vpu is identified to have a physical interaction with RAN binding protein 1 (RANBP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
18187620 Knockdown of RAN binding protein 1 (RANBP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells
17940066 These data indicate that RANBP1 activity is required for the proper localization of specific factors that regulate microtubule function; loss of this activity contributes to the generation of aneuploidy in a microtubule-dependent manner.
16428860 Phosphorylated wild type RanGAP1, but not a mutant harboring a mutation at the phosphorylation site 358S, efficiently formed a stable ternary complex with Ran and RanBP1 in vivo, suggesting that the 358S phosphorylation of RanGAP1 affects the Ran system.
14585972 structure of the Ran-RanBP1-RanGAP complex
9111043 HIV-1 Vpu is identified to have a physical interaction with RAN binding protein 1 (RANBP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses

AA Sequence


Text Mined References (60)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25772364 2015 SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
25743254 2015 Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25218447 2014 Uncovering global SUMOylation signaling networks in a site-specific manner.
25114211 2014 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23108393 2013 Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.
21998203 2011 Induction of Ran GTP drives ciliogenesis.
21813642 2011 Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
21184585 2011 Association of RANBP1 haplotype with smooth pursuit eye movement abnormality.
20658144 2010 Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.
20508983 2011 Centrosome-related genes, genetic variation, and risk of breast cancer.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19549784 2009 Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19270727 2009 RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17940066 2007 RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16428860 2005 Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.
16130169 2005 Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
16041368 2005 Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication.
15461802 2004 A genome annotation-driven approach to cloning the human ORFeome.
15459234 2005 CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14585972 2003 Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?
12852855 2003 The Ran GTPase regulates kinetochore function.
12840069 2003 Mammalian RanBP1 regulates centrosome cohesion during mitosis.
12649209 2003 E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner.
12606574 2003 Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11832950 2002 RanGAP mediates GTP hydrolysis without an arginine finger.
11804793 2002 RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction.
11278834 2001 Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.
10995230 2000 Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta.
10811801 2000 The mammalian Mog1 protein is a guanine nucleotide release factor for Ran.
10779340 2000 Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.
10591208 1999 The DNA sequence of human chromosome 22.
10471274 1999 Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1.
10454574 1999 RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase.
10330396 1999 A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export.
10318915 1999 Two distinct classes of Ran-binding sites on the nucleoporin Nup-358.
9428644 1997 RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors.
9315840 1997 Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1.
9271386 1997 Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1.
9111043 1997 Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1.
9045717 1997 Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97.
8909533 1996 RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import.
8255297 1993 Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
7891706 1995 Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.
7882974 1995 Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.
7616957 1995 RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.