Tdark RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2

Protein Summary

Description

Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity).

Uniprot Accession IDs

• Q86X27
• B7Z7B1
• Q5T5Z1
• Q5VZ67
• Q9NW78

Gene Name

• RALGPS2

Ensembl ID

• ENST00000367634
• ENSP00000356606
• ENSG00000116191
• ENST00000367635
• ENSP00000356607

Symbol

• dJ595C2.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
PubMedID	0.86
transcription factor binding site profile	0.81
small molecule perturbation	0.76
microRNA	0.72

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Ras-specific Guanine Nucleotide-releasing Factor Ralgps2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Ras-specific Guanine Nucleotide-releasing Factor Ralgps2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.68   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.68   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0