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Tdark Ral GTPase-activating protein subunit alpha-2

Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 5.19
PubTator Score 13.75

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Kidney cancer 2613 0.0 0.6
Disease Target Count Z-score Confidence
Hepatocellular Adenoma 10 3.614 1.8

Expression

  Differential Expression (12)

Disease log2 FC p
acute quadriplegic myopathy 1.247 3.7e-05
group 3 medulloblastoma 1.500 2.1e-04
intraductal papillary-mucinous adenoma (... 1.700 3.0e-05
intraductal papillary-mucinous carcinoma... 1.300 1.3e-03
intraductal papillary-mucinous neoplasm ... 1.900 1.0e-03
medulloblastoma, large-cell 1.400 1.6e-04
non-small cell lung cancer -1.338 1.7e-16
osteosarcoma -2.834 2.4e-06
ovarian cancer -1.100 7.1e-07
pancreatic ductal adenocarcinoma liver m... -1.374 4.2e-02
Pick disease 1.400 6.1e-06
psoriasis 1.100 2.7e-05

Synonym

Accession Q2PPJ7 Q4VXU6 Q5JUA3 Q5JUA4 Q5T9K3 Q96CX9 Q9BQT7 Q9H9D9 Q9ULE8
Symbols p220
AS250
C20orf74
dJ1049G11
bA287B20.1
dJ1049G11.4

Gene

RALGAPA2

PANTHER Protein Class (2)

  Ortholog (13)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (7)

 GO Function (2)

 GO Component (5)

 GO Process (2)

 Compartment GO Term (11)

 MGI Phenotype (2)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

Pathway (3)

Gene RIF (2)

AA Sequence 

MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYENFIALENSLK      1 - 70
LKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKIRCEGIRLFLLWLQAL     71 - 140
QTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPSVADVKIYPEEITPLLPAISGEKIAEDQTCF    141 - 210
FLQILLKYMVIQAASLEWKNKENQDTGFKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYI    211 - 280
TTTRDNENIYSTKIPYMAARVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELD    281 - 350
GGGPTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLLPSCEI    351 - 420
AVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGFSETDSKEASSESSGHKRSSSWGRTYSFTSA    421 - 490
MSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPCAEVPVLLKEQVDACKAVLIIFRRMIMELTMNK    491 - 560
KTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAGLLFRTLMVAWIRANLCVYISRELWDDFLGVLSSL    561 - 630
TEWEELINEWANIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWR    631 - 700
SHPDVTEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDI    701 - 770
PEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRE    771 - 840
RQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVADADARHWLQLSPTDASNLTDSSECLTD    841 - 910
DCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYELWYKLAKIRDNLAISLDNQS    911 - 980
SPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSE    981 - 1050
DQDILNTIIRHCPPRFFSLGFPGFSMLVGDFITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIPL   1051 - 1120
LQSVPEVNEAITGTEDVKHYLINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTSHPQVKEAINVIG   1121 - 1190
VTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLL   1191 - 1260
LCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYILTLADLSSTDY   1261 - 1330
DPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIPLTARMVMAHLVNHLGHYPLSGGPAILHS   1331 - 1400
LVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDSTLISYLQTPTEGPVGGSPVGSLSDVRVIVRDISGKY   1401 - 1470
SWDGKVLYGPLEGCLAPNGRNPSFLISSWHRDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQL   1471 - 1540
NLNEPSLTPCGMNYDQEKEIIEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDD   1541 - 1610
LGMNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAG   1611 - 1680
LGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWS   1681 - 1750
EHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGAIVSGKLLPSLVCATCINASR   1751 - 1820
AVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSLSGTD                    1821 - 1873
//

Text Mined References (18)

PMID Year Title