Tbio RAET1G UL-16 binding protein 5

Protein Summary

Description

Isoform 1: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Isoform 3: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG. Isoform 2: Stimulates natural killer cells to secrete IFNG. This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q6H3X3
• Q6H3X2

Gene Name

• RAET1G

Ensembl ID

• ENST00000367360
• ENSP00000356329
• ENSG00000203722
• ENST00000367361
• ENSP00000356330

Symbol

• ULBP5
• ULBP5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.69
histone modification site profile	0.53
cellular component	0.52
cell line	0.48
tissue	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.1   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 24   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.1   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0