Property Summary

NCBI Gene PubMed Count 16
PubMed Score 8.11
PubTator Score 8.92

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (15)

Disease log2 FC p
astrocytic glioma -1.100 2.4e-02
posterior fossa group B ependymoma -2.100 1.8e-07
oligodendroglioma -1.400 9.0e-03
osteosarcoma -4.687 7.4e-09
glioblastoma -1.900 6.3e-06
group 3 medulloblastoma -3.000 9.9e-04
atypical teratoid/rhabdoid tumor -2.400 4.2e-07
medulloblastoma, large-cell -2.400 1.8e-03
primitive neuroectodermal tumor -2.100 1.0e-02
tuberculosis 1.900 1.1e-07
pediatric high grade glioma -2.000 6.8e-05
pilocytic astrocytoma -2.100 1.2e-05
subependymal giant cell astrocytoma -2.092 1.7e-02
nasopharyngeal carcinoma -1.200 2.7e-05
head and neck cancer -1.300 2.7e-02

Gene RIF (5)

PMID Text
25183545 RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis.
23372429 Rab37 mRNA was specifically expressed in some ESCC cell lines but its genetic polymorphisms were not associated with esophageal squamous cell carcinoma.
22082156 Knockdown of RAB37, member RAS oncogene family by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N
19148500 the TMEM22/RAB37 complex is likely to play a crucial role in growth of renal cell carcinoma
18687502 Promoter/exon1 methylation is the predominant mechanism in down-regulation of the hRAB37, and can serve as a potential prediction biomarker of NSCLC progression.

AA Sequence

MTGTPGAVATRDGEAPERSPPCSPSYDLTGKVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFRNK      1 - 70
VVTVDGVRVKLQIWDTAGQERFRSVTHAYYRDAQALLLLYDITNKSSFDNIRAWLTEIHEYAQRDVVIML     71 - 140
LGNKADMSSERVIRSEDGETLAREYGVPFLETSAKTGMNVELAFLAIAKELKYRAGHQADEPSFQIRDYV    141 - 210
ESQKKRSSCCSFM                                                             211 - 223
//

Text Mined References (17)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25183545 2014 Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
23969696 2013 Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
23372429 2013 An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.
20031577 2009 Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
19148500 2009 Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
18687502 2009 Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15308636 2004 Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12665801 2003 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12578829 2003 Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10722846 2000 Rab37 is a novel mast cell specific GTPase localized to secretory granules.