Tbio Q9BZG1 Ras-related protein Rab-34

Protein Summary

Description

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity). This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q9BZG1
• B4E3A0
• E9PEJ9
• Q5BJE6
• Q8NCJ8
• Q96AR4

Gene Name

• RAB34

Ensembl ID

• ENST00000301043
• ENSP00000301043
• ENSG00000109113
• ENST00000395245
• ENSP00000378666
• ENST00000415040
• ENSP00000410279
• ENST00000436730
• ENSP00000404180
• ENST00000450529
• ENSP00000391048

Symbol

• RAB39
• RAH
• RAH
• NARR
• RAB39

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
cellular component	0.89
kinase perturbation	0.84
virus perturbation	0.79
transcription factor binding site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.32   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.32   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0