| Tbio | Rab11 family-interacting protein 1 |
A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.
This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.7e-23 |
| non-small cell lung cancer | 2890 | 2.1e-12 |
| lung adenocarcinoma | 2716 | 1.8e-11 |
| cystic fibrosis | 1696 | 6.9e-08 |
| ulcerative colitis | 1819 | 9.5e-07 |
| pituitary cancer | 1972 | 5.4e-06 |
| ependymoma | 4679 | 2.4e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.7e-05 |
| nasopharyngeal carcinoma | 1058 | 2.0e-04 |
| interstitial cystitis | 2312 | 4.7e-04 |
| Atopic dermatitis | 952 | 1.6e-03 |
| ovarian cancer | 8520 | 1.6e-03 |
| lung cancer | 4740 | 1.6e-03 |
| oligodendroglioma | 2850 | 2.9e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.1e-03 |
| Rheumatoid arthritis | 1191 | 4.8e-03 |
| invasive ductal carcinoma | 2951 | 5.1e-03 |
| primitive neuroectodermal tumor | 3035 | 6.0e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 6.9e-03 |
| osteosarcoma | 7950 | 1.4e-02 |
| ductal carcinoma in situ | 1745 | 3.3e-02 |
| spina bifida | 1074 | 3.7e-02 |
| acute myeloid leukemia | 783 | 4.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.400 | 4.8e-02 |
| Atopic dermatitis | -1.200 | 1.6e-03 |
| atypical teratoid / rhabdoid tumor | 4.000 | 6.7e-05 |
| cystic fibrosis | -2.850 | 6.9e-08 |
| ductal carcinoma in situ | 1.500 | 3.3e-02 |
| ependymoma | 1.400 | 2.4e-05 |
| interstitial cystitis | -1.100 | 4.7e-04 |
| intraductal papillary-mucinous carcinoma... | 1.200 | 6.9e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.000 | 3.1e-03 |
| invasive ductal carcinoma | 1.900 | 5.1e-03 |
| lung adenocarcinoma | -1.300 | 1.8e-11 |
| lung cancer | -2.900 | 1.6e-03 |
| lung carcinoma | -1.100 | 2.7e-23 |
| nasopharyngeal carcinoma | -1.200 | 2.0e-04 |
| non-small cell lung cancer | -1.556 | 2.1e-12 |
| oligodendroglioma | -1.100 | 2.9e-03 |
| osteosarcoma | -1.584 | 1.4e-02 |
| ovarian cancer | -1.600 | 1.6e-03 |
| pituitary cancer | -1.400 | 5.4e-06 |
| primitive neuroectodermal tumor | 1.200 | 6.0e-03 |
| Rheumatoid arthritis | -1.100 | 4.8e-03 |
| spina bifida | -2.079 | 3.7e-02 |
| ulcerative colitis | -1.300 | 9.5e-07 |
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEA 1 - 70 TFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERG 71 - 140 EIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKD 141 - 210 KKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTAS 211 - 280 TDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFR 281 - 350 KKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT 351 - 420 KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKD 421 - 490 TAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDS 491 - 560 PSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL 561 - 630 LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETG 631 - 700 RQEEELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEE 701 - 770 VAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQELNP 771 - 840 AWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEASSAKDTPL 841 - 910 FRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGD 911 - 980 QVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFG 981 - 1050 IHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHH 1051 - 1120 TSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVA 1121 - 1190 NCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLV 1191 - 1260 RVMEETPNILRIPTQVGKKAGKM 1261 - 1283 //
