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Tbio Rab11 family-interacting protein 1

A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]

 Comments

Property Summary

NCBI Gene PubMed Count 33
PubMed Score 16.77
PubTator Score 30.34

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Expression

  Differential Expression (23)

Disease log2 FC p
Rheumatoid Arthritis -1.100 4.8e-03
oligodendroglioma -1.100 2.9e-03
osteosarcoma -1.584 1.4e-02
posterior fossa group A ependymoma 1.500 7.6e-09
cystic fibrosis -2.850 6.9e-08
atypical teratoid / rhabdoid tumor 4.000 6.7e-05
primitive neuroectodermal tumor 1.200 6.0e-03
Atopic dermatitis -1.200 1.6e-03
non-small cell lung cancer -2.058 3.6e-17
intraductal papillary-mucinous carcinoma... 1.200 6.9e-03
intraductal papillary-mucinous neoplasm ... 2.000 3.1e-03
lung cancer -2.900 1.6e-03
interstitial cystitis -1.200 2.1e-04
lung adenocarcinoma -1.400 1.2e-07
nasopharyngeal carcinoma -1.200 2.0e-04
lung carcinoma -1.100 2.7e-23
spina bifida -2.122 3.6e-02
ductal carcinoma in situ 1.500 3.3e-02
invasive ductal carcinoma 1.900 5.1e-03
acute myeloid leukemia 1.400 4.8e-02
ulcerative colitis -1.300 9.5e-07
ovarian cancer 2.300 7.7e-06
pituitary cancer -1.400 5.4e-06

Synonym

Accession Q6WKZ4 J3KNP0 Q307T1 Q6AZK4 Q6WKZ2 Q6WKZ6 Q86YV4 Q8TDL1 Q9H642 Rab11-FIP1
Symbols RCP
NOEL1A
rab11-FIP1

Gene

RAB11FIP1

PDB

4D0G  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (11)

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 GO Function (1)

 GO Component (4)

 GO Process (3)

 Compartment GO Term (35)

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 HCA RNA Cell Line (56)

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Pathway (2)

Protein-protein Interaction (3)

NOLC1   YWHAG   YWHAZ  

Gene RIF (25)

PMID Text
26790954 Rab11-FIP1A associates with and regulates trafficking at an early step in the process of membrane recycling
26152716 GTPase Rab11, but not Rab4, is involved in the recycling of hERG channels.
26034275 Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types
26032412 We find that Rab14 indeed binds to RCP, albeit with reduced affinity relative to conventional Rab11-FIP and Rab25-FIP complexes. However, in vivo, Rab11 recruits RCP onto biological membranes.
24302731 Mitochondrial remodeling was associated with increased proximity between Rab11a and mitochondrial membranes, changes in fusion-fission dynamics, and mitochondrial relocalization of the Drp1, which was regulated by the Rab11a effector protein FIP1/RCP.
24040321 rab11 effector protein FIP1 regulates adiponectin trafficking and secretion
23592992 findings support a model for HIV-1 Env incorporation in which specific targeting to the particle assembly microdomain on the plasma membrane is mediated by FIP1C and Rab14
23592992 Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types
23592992 Knockdown of RAB11-FIP1C by shRNA inhibits HIV-1 infectivity in TZM-bl cells
23283983 These findings suggest that Rab11-FIP1 proteins participate in spatially and temporally distinct steps of the recycling process along a complex and dynamic tubular network in which Rab11-FIPs occupy discrete domains
22188018 Rab11 is differentially phosphorylated by distinct PKC isoenzymes; this post-translational modification might be a regulatory mechanism of intracellular trafficking.
21640764 results suggest that Rab5 is involved in CB2 endocytosis and that internalized receptors are recycled via a Rab11 associated pathway rather than the rapid Rab4 associated pathway.
20810886 An interaction with Rab11 is necessary for long-range targeting of beta1 integrins to the growth cone along axons and in neurons.
20610657 FIP1/RCP binding to Golgin-97 is required for tethering and fusion of recycling endosome-derived retrograde transport vesicles to the trans-Golgi network.
19620787 RCP is a human breast cancer-promoting gene with Ras-activating function.
18838556 RCP provides a scaffold that promotes the physical association and coordinate trafficking of alpha5beta1 and EGFR1 and that this drives migration of tumor cells into three-dimensional matrices.
16920206 identified eight alternatively spliced Rab11-FIP1 gene transcripts from human chromosome 8
16216915 Results describe the endometrial expression of Rab coupling protein and its hormonal regulation.
16049696 Rab11 and microtubules maintain the proper distribution of the subapical AQP2 storage compartment, and actin filaments regulate the trafficking of AQP2 from early endosomes to the storage compartment.
15769254 once the Rab11/RCP-regulated cargo has been delivered from the endocytic recycling compartment to the plasma membrane, RCP is inactivated by calpain-mediated proteolysis
15355514 Acting as an intermediate between Rab4 and Rab11, RCP regulates membrane flux along the phagocytic pathway via recycling events.
15280022 Rab11, rather than Rab4, mediates the intracellular localisation of RCP.
15181150 RCP functions primarily as a Rab11 binding protein that regulates protein sorting in tubular endosomes.
15134434 Receptor cell surface expression and endocytosis experiments reveal that the small GTPase Rab11 protein is a determinant factor in controlling thromboxane A2 receptor beta isoform recycling back to the cell surface.
11786538 Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein

AA Sequence 

MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEA      1 - 70
TFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERG     71 - 140
EIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKD    141 - 210
KKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTAS    211 - 280
TDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFR    281 - 350
KKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT    351 - 420
KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKD    421 - 490
TAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDS    491 - 560
PSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL    561 - 630
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETG    631 - 700
RQEEELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEE    701 - 770
VAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQELNP    771 - 840
AWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEASSAKDTPL    841 - 910
FRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGD    911 - 980
QVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFG    981 - 1050
IHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHH   1051 - 1120
TSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVA   1121 - 1190
NCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLV   1191 - 1260
RVMEETPNILRIPTQVGKKAGKM                                                  1261 - 1283
//

Text Mined References (43)

PMID Year Title
26790954 2016 Rab11-FIP1A regulates early trafficking into the recycling endosomes.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26152716 2015 Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel.
26032412 2015 Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP).
24302731 2014 A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24144296 2013 Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
24040321 2013 The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion.
23592992 2013 Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex.
23283983 2013 Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22188018 2012 Rab11 is phosphorylated by classical and novel protein kinase C isoenzymes upon sustained phorbol ester activation.
21640764 2011 Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20810886 2010 Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.
20610657 2010 FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19620787 2009 RCP is a human breast cancer-promoting gene with Ras-activating function.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18838556 2008 Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16964243 2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
16920206 2006 The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system.
16421571 2006 DNA sequence and analysis of human chromosome 8.
16216915 2005 Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium.
16049696 2005 Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments.
15769254 2005 Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15355514 2004 Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment.
15280022 2004 Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis.
15181150 2004 The RCP-Rab11 complex regulates endocytic protein sorting.
15134434 2004 Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11944901 2002 The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities.
11786538 2002 Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.
11495908 2001 Identification and characterization of a family of Rab11-interacting proteins.