Property Summary

NCBI Gene PubMed Count 32
PubMed Score 60.32
PubTator Score 14.21

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count
HIV Infections 99
Disease Target Count P-value
psoriasis 6685 2.1e-06
group 4 medulloblastoma 1875 1.9e-03
glioblastoma 5572 2.3e-03
osteosarcoma 7933 2.6e-03
atypical teratoid / rhabdoid tumor 4369 8.8e-03
Disease Target Count Z-score Confidence
Lipid metabolism disorder 102 0.0 2.0
Disease Target Count Z-score Confidence
Rectum cancer 12 6.285 3.1

Expression

  Differential Expression (5)

Disease log2 FC p
psoriasis -4.600 2.1e-06
osteosarcoma -1.550 2.6e-03
atypical teratoid / rhabdoid tumor 1.100 8.8e-03
glioblastoma 1.100 2.3e-03
group 4 medulloblastoma 1.600 1.9e-03

Gene RIF (13)

PMID Text
26635365 Rab11A and Rab11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
25070890 we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions
24589086 Upon Rab11b depletion, FGFR4 is trapped in the pericentriolar recycling compartment.
24141907 the predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by Rab11b through remodeling of the melanosome membrane, followed by subsequent endocytosis by keratinocytes
22561749 Data show that the cAMP/PKA/CREB signaling pathway initiates acidosis-induced V-ATPase trafficking in salivary ducts via regulation of Rab11b expression.
21248079 These findings reveal a novel role for Rab11b in limiting, rather than promoting, the plasma membrane expression of Cav1.2 L-type Ca2+ channels.
20877624 Observational study of gene-disease association. (HuGE Navigator)
20717956 These data introduce Rab11b as a crucial regulator and Rip11 as mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland.
20686666 propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature Inner Membrane Complex of the growing daughter parasites.
20622010 RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane
19244346 This is the first report detailing apical CFTR recycling in a native expression system and to demonstrate that Rab11b regulates apical recycling in polarized epithelial cells.
16545962 structural analysis shows Rab11 isoforms may possess different GTP hydrolysis rates
15569681 RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane

AA Sequence

MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQ      1 - 70
ERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEAR     71 - 140
AFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPN    141 - 210
KLQCCQNL                                                                  211 - 218
//

Text Mined References (39)

PMID Year Title
26635365 2016 Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25556234 2015 New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25070890 2014 Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions.
24589086 2014 Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling.
24141907 2014 Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.
24023390 2013 Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.
24006491 2013 Identification and characterization of multiple novel Rab-myosin Va interactions.
23572552 2013 ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22613832 2012 TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
22561749 2012 Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression.
22129970 2012 Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC).
21976701 2011 Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.
21269460 2011 Initial characterization of the human central proteome.
21255211 2011 Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.
21248079 2011 Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20717956 2011 Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts.
20686666 2010 Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
19244346 2009 Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells.
19060906 2009 Common variants at 30 loci contribute to polygenic dyslipidemia.
19029296 2009 Small GTPase determinants for the Golgi processing and plasmalemmal expression of human ether-a-go-go related (hERG) K+ channels.
16545962 2006 The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
15057824 2004 The DNA sequence and biology of human chromosome 19.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14627637 2003 Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11495908 2001 Identification and characterization of a family of Rab11-interacting proteins.
11481332 2001 Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins.
11408590 2001 Myosin vb is associated with plasma membrane recycling systems.
10942597 2000 Rab11b is essential for recycling of transferrin to the plasma membrane.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
7811277 1994 Molecular cloning of two small GTP-binding proteins from human skeletal muscle.