Property Summary

NCBI Gene PubMed Count 119
PubMed Score 398.89
PubTator Score 281.07

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (13)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.304 5.4e-03
Multiple myeloma 1.262 5.2e-03
psoriasis 1.100 4.9e-04
medulloblastoma, large-cell -1.200 2.0e-02
acute quadriplegic myopathy 1.180 7.0e-07
primary pancreatic ductal adenocarcinoma 1.137 7.1e-03
non-small cell lung cancer -1.424 8.5e-18
intraductal papillary-mucinous neoplasm ... 1.600 2.5e-03
interstitial cystitis -1.200 4.4e-05
Pick disease -1.200 1.7e-03
ovarian cancer 1.900 8.2e-04
pancreatic cancer 1.100 4.9e-03
dermatomyositis 1.200 1.7e-03

Gene RIF (73)

PMID Text
26879265 Substituted V20 of Rab11A was found to interfere with proper localization of the water molecule, which mediated GTP hydrolysis, resulting in GTP being locked in an active form of Rab11A S20V.
26663395 Rab11a/Rab11 family-interacting protein 2-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity.
26637356 Data (including data from studies in knockout mice) suggest Munc13-4 binds to Rab11 and regulates trafficking of Rab11-containing vesicles; Munc13-4 appears to regulate final steps of Rab11-positive vesicle docking at plasma membrane in exocytosis.
26635365 Rab11A and Rab11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
26378159 Mumps Virus release from the apical surface of polarized epithelial cells is facilitated by a Rab11-mediated transport system.
26258637 Authors show that Rab11-GMPPNP-FIP3-Rabin8 is more stable than Rab11-GMPPNP-Rabin8, owing to direct interaction between Rabin8 and FIP3 within the dual effector-bound complex.
26041286 Vaccinia virus traffics to early endosomes, where recycling endosome markers Rab11 and Rab22 are recruited to participate in subsequent virus trafficking prior to virus core uncoating in the cytoplasm.
25673875 Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment
25446083 Rab11-dependent EGFR recycling has a role in synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M
25299335 Additionally, Rab11 recruitment is absent and Shigella-containing vacuolar rupture is delayed in the ipgD mutant that does not dephosphorylate PI(4,5)P2 into PI(5)P.
25117932 Data demonstrated that Rab11 regulated E-cadherin expression and promoted colon cancer cell transformation.
25092884 Rab11 co-localizes with alpha-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
24962317 PI4KIIIbeta likely plays a role in breast oncogenesis and that cooperation between Rab11a and PI4KIIIbeta represents a novel Akt activation pathway.
24920821 Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation
24892806 Microvilli establishment required interaction between RAB8A and MYO5B, while loss of the interaction between RAB11A and MYO5B induced microvillus inclusions.
24876499 these data provide a mechanism for how PI4KIIIbeta coordinates Rab11 and its effectors on PI4P-enriched membranes and also provide strategies for the design of specific inhibitors that could potentially target plasmodial PI4KIIIbeta to combat malaria.
24830293 Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation
24413175 Part of the machinery for ezrin activation depends on recycling endosomes controlled by myosin Vb and Rab11a.
24373285 Rab11A controls BACE1 recycling to endosomes and thus affects beta-amyloid production.
24302731 Mitochondrial remodeling was associated with increased proximity between Rab11a and mitochondrial membranes, changes in fusion-fission dynamics, and mitochondrial relocalization of the Drp1, which was regulated by the Rab11a effector protein FIP1/RCP.
24190883 Ubiquitylation and activation of RAB11a is promoted by a beta2 adrenergic receptor-HACE1 complex.
24163434 p0071 has a key role in regulating recycling through the Rab11a-dependent perinuclear recycling compartment.
23733193 Data indicate that Rab5, Rab7 and Rab11 are involved in RGS4 traffics through plasma membrane recycling or endosome.
23640058 Data indicate that alpha2-macroglobulin (alpha2M*), through its receptor LRP1, induces cellular migration of Muller glial cells by a mechanism that involves MT1-MMP intracellular traffic to the plasma membrane by a Rab11-dependent recycling pathway.
23454239 Dominant negative (GDP-locked)-Rab5 and -Rab11 reproduced the effects of inhibitors of tubulin and actin, respectively, on the cycling of bradykinin B receptor.
23283983 These findings suggest that Rab11-FIP1 proteins participate in spatially and temporally distinct steps of the recycling process along a complex and dynamic tubular network in which Rab11-FIPs occupy discrete domains.
23176490 The potential roles of the Rab11 pathway in the trafficking, assembly and budding steps of negative-strand viruses.
22981775 findings show 2 mother centriole appendage proteins, centriolin and cenexin/ODF2, regulate association of the endosome components Rab11, the Evi5, and the exocyst at the mother centriole
22685325 Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor beneath the plasma membrane.
22613832 TBC1D14 binds activated Rab11 but is not a GAP for Rab11, and loss of Rab11 prevents TBC1D14-induced tubulation of recycling endosomes.
22537031 miR-141/YWHAG and miR-520e/RAB11A are two potential miRNA/protein target pairs associated with severe obesity.
22420646 Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane
22404213 Knockdown of RAB11A, member RAS oncogene family (RAB11A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells
22303009 Our data suggest a selective role of PICK1 in clustering and reducing the recycling rates of PDZ domain binding partners sorted to the Rab11-dependent recycling pathway.
21789505 Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation
21586748 Recycling was accompanied by dephosphorylation of VEGFR-2 between Rab4 and Rab11 vesicles and quantitatively and qualitatively altered signal output.
21525351 Our results uncover a critical host factor with an essential contribution to influenza virus genome delivery and reveal a potential role for RAB11A in the transport of ribonucleoprotein cargo.
21307188 The authors propose that influenza virus ribonucleoproteins are routed from the nucleus to the pericentriolar recycling endosome (RE), where they access a Rab11-dependent vesicular transport pathway to the cell periphery.
21282656 Rab11a, but not Rab8a, is required for recycling of transferrin in nonpolarized cells.
21273506 Rabin8 and Rab11 are associated with the Bardet-Biedl syndrome.
20933442 Rab11a is an important regulator of TLR4 and Toll-receptor-associated molecule transport to E. coli phagosomes thereby controlling IRF3 activation from this compartment.
20877624 Observational study of gene-disease association. (HuGE Navigator)
20727405 Rab11a played a prominent role in recycling of the wild type ss1-adrenergic receptors because dominant negative rab11a inhibited.
20622010 Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation
20395296 characterization of a novel Rab11 binding domain within alpha-helix 8 of the prostacyclin receptor that is regulated by palmitoylation
20357086 Transmission electron microscopy of thin sections confirmed that Rab11 depletion resulted in significant numbers of abnormally formed virus particles that had failed to pinch off from the plasma membrane.
20346379 Results describe the involvement of two Rab GTPases, Rab9 and Rab11, in the trafficking of TRPC6.
20308558 Rab11, in its GTP-bound form, interacts with Rabin8 and kinetically stimulates the guanine nucleotide-exchange activity of Rabin8 toward Rab8.
20026645 Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells.
19996123 Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway.
19797056 D-AKAP2 promotes accumulation of recycling proteins in the Rab4/Rab11-positive endocytic recycling compartment
19752198 A novel mechanism for cellular dysfunction by the HD mutation arising from the inhibition of Rab11 activity and a deficit in vesicle formation at recycling endosomes, is proposed.
19641023 Recycling endosome trafficking to the Golgi complex through a pathway involving Src-family kinases, Cdc42, and Rab11a plays a general role in death signaling by mediating regulated changes in Golgi dynamics.
19460752 Knockdown of RAB11A, member RAS oncogene family (RAB11A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells
19193894 Both rab11a and HSP90 appear to be involved in the process of exocytosis of internalized extracellular alpha-synuclein.
18843107 Rab11a was expressed in umbrella cells (but not Rab11b or Rab25) and was associated with discoidal/fusiform vesicles, which were dependent on the activity of the Rab11a GTPase for exocytosis.
18701709 endosomal activation of the PI3K/AKT signaling pathway in response to Gbetagamma trafficking, via its interaction with Rab11, is a relevant step in the mechanism controlling cell survival and proliferation
18550774 Both phosphorylated and nonphosphorylated MOR internalize via Rab5-dependent pathway after agonist stimulation, and the phosphorylated and nonphosphorylated MORs recycle through distinct vesicular trafficking pathways mediated by Rab4 and Rab11.
18406652 Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation
17854769 These data therefore show that (i) Rab11a regulates cell surface abundance of both GLUT4 and FAT/CD36.
17538027 These results show that Rab11A and Langerin are required for BG biogenesis, and they illustrate the role played by a Rab GTPase in the formation of a specialized subcompartment within the endocytic-recycling system.
17476295 Rab11 plays a role in the intracellular trafficking of various types of LG-molecule from the TGN to the cell surface
17462998 myosin Vb is required for CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells
17426287 CaR is constitutively endocytosed and recycled to the plasma membrane by a Rab11a-dependent mechanism.
17157409 Rab 11 and Arf6 function synergistically in the switch from furrowing to abscission, as well as in the terminal stage of abscission
17030804 Results describe the distinct C-terminal binding regions of FIP3 and FIP4 for Rab11 and ARF5/ARF6, and the crystal structure of Rab11 in complex with the Rab11-binding domain (RBD) of FIP3.
16473307 We conclude that the glutamine residue of Rab11a at position 70 is not strictly essential for GTPase activity of this protein in contrast to Ras and other Rab proteins.
16214890 Data suggest that polarization of hepatocytes requires recruitment of rab11a and myosin Vb to intracellular membranes that contain apical ABC transporters and transcytotic markers.
16126723 an interaction between Rab11 and TPbeta directs TPbeta recycling
15569681 Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation
15190120 there is a pivotal role for rab11 in regulating the traffic of a G protein-coupled receptor at the level of the recycling endosome
15188492 Rab11a, RPL7, and RPL28 showed moderate levels of differential expression in esophageal squamous cell carcinoma
14699104 mutation impairs a specific subset of Rab11 interactions, possibly those involved in cytoskeleton-based movements driving the slow recycling pathway

AA Sequence

MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQ      1 - 70
ERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEAR     71 - 140
AFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKV    141 - 210
QCCQNI                                                                    211 - 216
//

Text Mined References (129)

PMID Year Title
26879265 2016 Molecular mechanism of constitutively active Rab11A was revealed by crystal structure of Rab11A S20V.
26663395 2016 Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function.
26637356 2016 Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.
26635365 2016 Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.
26506309 2015 REI-1 Is a Guanine Nucleotide Exchange Factor Regulating RAB-11 Localization and Function in C. elegans Embryos.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26378159 2015 Mumps Virus Is Released from the Apical Surface of Polarized Epithelial Cells, and the Release Is Facilitated by a Rab11-Mediated Transport System.
26258637 2015 Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.
26041286 2015 Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25673875 2015 Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes.
25556234 2015 New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
25446083 2014 Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling.
25299335 2014 Shigella subverts the host recycling compartment to rupture its vacuole.
25117932 2014 Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma.
25092884 2014 The small GTPase Rab11 co-localizes with ?-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
24962317 2014 The lipid kinase PI4KIII? is highly expressed in breast tumors and activates Akt in cooperation with Rab11a.
24892806 2014 Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.
24876499 2014 Structures of PI4KIII? complexes show simultaneous recruitment of Rab11 and its effectors.
24648492 2014 Casein kinase 1? functions at the centrosome and Golgi to promote ciliogenesis.
24591568 2014 FIP5 phosphorylation during mitosis regulates apical trafficking and lumenogenesis.
24561039 2014 Rab11 endosomes contribute to mitotic spindle organization and orientation.
24413175 2014 Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes.
24373285 2013 A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of ?-amyloid production.
24302731 2014 A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.
24190883 2014 Ubiquitylation and activation of a Rab GTPase is promoted by a ??AR-HACE1 complex.
24163434 2014 The armadillo protein p0071 is involved in Rab11-dependent recycling.
24023390 2013 Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.
24006491 2013 Identification and characterization of multiple novel Rab-myosin Va interactions.
23733193 2013 Rab family proteins regulate the endosomal trafficking and function of RGS4.
23640058 2013 Activated ?2-macroglobulin induces Müller glial cell migration by regulating MT1-MMP activity through LRP1.
23535298 2013 UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23454239 2013 Inhibitory effects of cytoskeleton disrupting drugs and GDP-locked Rab mutants on bradykinin B? receptor cycling.
23283983 2013 Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system.
23176490 2012 Role of the Rab11 pathway in negative-strand virus assembly.
22981775 2012 The centrosome regulates the Rab11- dependent recycling endosome pathway at appendages of the mother centriole.
22685325 2012 Rab11 regulates exocytosis of recycling vesicles at the plasma membrane.
22613965 2012 The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration.
22613832 2012 TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
22537031 2012 miRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesity.
22420646 2012 A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane.
22303009 2012 Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway.
21976701 2011 Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.
21586748 2011 Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.
21525351 2011 RAB11A is essential for transport of the influenza virus genome to the plasma membrane.
21307188 2011 A Rab11- and microtubule-dependent mechanism for cytoplasmic transport of influenza A virus viral RNA.
21282656 2011 Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.
21273506 2011 Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.
21269460 2011 Initial characterization of the human central proteome.
21255211 2011 Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.
20933442 2010 The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes.
20890297 2010 A molecular network for de novo generation of the apical surface and lumen.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20727405 2011 Rab11a and its binding partners regulate the recycling of the ß1-adrenergic receptor.
20395296 2010 Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation.
20357086 2010 The Rab11 pathway is required for influenza A virus budding and filament formation.
20346379 2010 Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6.
20308558 2010 Coordination of Rab8 and Rab11 in primary ciliogenesis.
20190753 2010 Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization.
20026645 2010 Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment.
19996123 2010 Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway.
19797056 2009 D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling.
19752198 2009 Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.
19641023 2009 Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a.
19542231 2009 Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface.
19193894 2009 Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein.
18843107 2008 Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells.
18701709 2008 G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction.
18570918 2008 Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.
18550774 2008 Phosphorylation state of mu-opioid receptor determines the alternative recycling of receptor via Rab4 or Rab11 pathway.
18511905 2008 Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.
18329369 2008 Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.
17854769 2007 FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells.
17562788 2007 Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.
17538027 2007 Rab11A controls the biogenesis of Birbeck granules by regulating Langerin recycling and stability.
17476295 2007 Rab11 is associated with epidermal lamellar granules.
17462998 2007 Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells.
17426287 2007 Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
17229837 2007 Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.
17157409 2007 Role of endosomal Rab GTPases in cytokinesis.
17082457 2006 Protrudin induces neurite formation by directional membrane trafficking.
17030804 2006 Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.
17007872 2006 Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes.
16905101 2006 Crystal structure of rab11 in complex with rab11 family interacting protein 2.
16791210 2006 Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.
16730941 2006 A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
16572171 2006 Analysis of the DNA sequence and duplication history of human chromosome 15.
16473307 Identification and characterization of a novel variant in the highly conserved catalytic center of Rab11a.
16214890 2005 Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
16148947 2005 Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.
16126723 2005 The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11.
16034420 2005 Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
15837192 2005 Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein.
15689490 2005 Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin.
15634213 2005 Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner.
15601896 2005 The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15326289 2004 Identification and proteomic profiling of exosomes in human urine.
15304524 2004 The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane.
15280022 2004 Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis.
15229288 2004 Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment.
15190120 2004 Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors.
15188492 2004 Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression.
15181150 2004 The RCP-Rab11 complex regulates endocytic protein sorting.
15173169 2004 Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14699104 2004 The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes.
12540381 2003 Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12470645 2002 Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.
12435603 2002 Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton.
12145319 2002 Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.
11994279 2002 Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain.
11786538 2002 Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.
11495908 2001 Identification and characterization of a family of Rab11-interacting proteins.
11481332 2001 Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins.
11408590 2001 Myosin vb is associated with plasma membrane recycling systems.
11163216 2000 A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes.
10512627 1999 General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications.
10464283 1999 Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling.
10369872 1999 Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport.
10077598 1999 Identification of a putative effector protein for rab11 that participates in transferrin recycling.
9719562 1998 Rab11a is modified in vivo by isoprenoid geranylgeranyl.
9662449 1998 Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins.
1711847 1991 Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver.
1704119 1991 Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3.