Tchem QARS Glutamine--tRNA ligase

Protein Summary

Description

Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• P47897
• B4DWJ2

Gene Name

• QARS

Ensembl ID

• ENST00000306125
• ENSP00000307567
• ENSG00000172053
• ENST00000414533
• ENSP00000390015

Symbol

• GLNRS
• MSCCA
• PRO2195

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
interacting protein	0.97
histone modification site profile	0.92
molecular function	0.9
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Ligase / Glutamine--trna Ligase

DTO Classes

Protein / Enzyme / Ligase / Glutamine--trna Ligase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.78   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.78   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0