Tdark MAU2 chromatid cohesion factor homolog

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Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase.

Comments

Property Summary

NCBI Gene PubMed Count	15
PubMed Score	96.62

PubTator Score	74.42

Knowledge Summary

Patent

No data available

TINX Plot

Disease (1)

JensenLab Text Mining

Disease	Target Count	Z-score	Confidence
Cornelia de Lange syndrome	21	4.289	2.1
Cancer	2499	4.277	2.1

Uterus 17,618

Ovary 17,971

Brain - Cerebellum 17,983

Brain - Cerebellar Hemisphere 18,015

Nerve - Tibial 18,007

Spleen 17,614

Testis 18,518

Thyroid 18,024

Vagina 17,834

Pituitary 18,147

Artery - Aorta 17,896

Artery - Coronary 17,949

Skin - Sun Exposed (Lower leg) 17,968

Artery - Tibial 17,631

Prostate 18,213

Skin - Not Sun Exposed (Suprapubic) 18,081

Small Intestine - Terminal Ileum 17,954

Colon - Sigmoid 18,089

Adipose - Subcutaneous 18,110

Esophagus - Gastroesophageal Junction 18,000

Esophagus - Mucosa 18,076

Breast - Mammary Tissue 18,103

Esophagus - Muscularis 18,017

Lung 18,057

Adipose - Visceral (Omentum) 17,937

Brain - Spinal cord (cervical c-1) 17,973

Muscle - Skeletal 17,778

Adrenal Gland 18,071

Minor Salivary Gland 18,005

Cells - EBV-transformed lymphocytes 18,186

Cells - Transformed fibroblasts 17,577

Stomach 17,879

Brain - Cortex 18,039

Colon - Transverse 17,825

Whole Blood 17,439

Brain - Hypothalamus 18,169

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Frontal Cortex (BA9) 18,069

Heart - Atrial Appendage 17,896

Brain - Substantia nigra 17,981

Brain - Caudate (basal ganglia) 18,001

Kidney - Cortex 17,329

Pancreas 18,123

Brain - Hippocampus 18,011

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Putamen (basal ganglia) 17,863

Brain - Amygdala 18,006

Liver 18,071

Heart - Left Ventricle 18,006

CD8 Cells 9,840

B Cells 9,086

CD4 Cells 7,773

Adult Ovary 10,192

Monocytes 7,422

NK Cells 8,475

Adult Testis 10,836

Fetal Ovary 9,118

Adult Retina 10,115

Adult Pancreas 9,168

Fetal Heart 9,228

Heart

B-lymphocyte

Monocyte

Natural killer cell

Ovary

Pancreas

Retina

Testis

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

Peripheral nervous system 184

Testis 3,897

Thymus 427

Choriocarcinoma cell 33

See source...

Tongue cancer cell line 8

Oral cancer cell 20

Oral squamous cell carcinoma cell 17

Tongue cancer cell 9

SCC-25 cell 2

Keratinocyte 9

OECM-1 cell 4

Detroit-562 cell 1

Oral mucosa 56

Chlorenchyma 6

Dok 24

Head and neck cancer cell 13

See source...

Synonym

Accession	Q9Y6X3 Q66PT1 Q6P3S7 Q6ZTT2 Q9UFX8 MAU-2
Symbols	SCC4 MAU2L mau-2 KIAA0892

Gene

MAU2

Ortholog (11)

Species	Source	Disease
Chicken 7,827	Inparanoid OMA
Xenopus 10,468	Inparanoid OMA
Opossum 12,230	Inparanoid OMA
Platypus 5,703	Inparanoid OMA
C. elegans 3,179	Inparanoid OMA
Fruitfly 3,050	Inparanoid OMA
Mouse 16,570	Inparanoid OMA
Horse 14,252	Inparanoid OMA
Cow 15,320	Inparanoid OMA
Rat 15,117	Inparanoid OMA
Dog 15,073	Inparanoid OMA

UniProt Keyword (11)

Complete proteome 20,231

Nucleus 5,259

Polymorphism 12,194

Reference proteome 20,231

Repeat 4,916

Alternative splicing 10,528

Cell cycle 647

Cell division 383

Mitosis 273

TPR repeat 166

See all...

GO Function (2)

protein N-terminus binding 106

double-stranded DNA binding 79

GO Component (5)

nucleus 5,097

nucleoplasm 2,996

nuclear body 266

chromatin 84

SMC loading complex 2

GO Process (2)

cell division 345

maintenance of mitotic sister chromatid ... 4

Compartment GO Term (31)

Cell 16,178

Cell part 16,177

Chromatin 565

Chromosomal part 889

Chromosome 1,039

Cohesin complex 48

GO:0000793 220

Intracellular 14,109

Intracellular membrane-bounded organelle 10,341

Intracellular non-membrane-bounded organ... 3,975

Intracellular organelle 12,025

Intracellular organelle lumen 5,090

Intracellular organelle part 8,783

Intracellular part 13,972

Macromolecular complex 5,475

See all...

IMPC Phenotype (6)

preweaning lethality, complete penetranc... 979

decreased body length 101

abnormal lens morphology 81

absent pinna reflex 23

cataract 92

vertebral transformation 12

MGI Phenotype (10)

growth-size-body region phenotype 4,157

cellular phenotype 3,637

craniofacial phenotype 1,182

vision-eye phenotype 1,622

hearing-vestibular-ear phenotype 767

hematopoietic system phenotype 3,383

mortality-aging 5,018

embryo phenotype 1,827

skeleton phenotype 2,222

immune system phenotype 3,461

GWAS Trait (9)

Plateletcrit 227

Schizophrenia 533

Tonsillectomy 149

White blood cell count (basophil) 64

Bipolar disorder 94

LDL cholesterol 110

Triglycerides 87

Response to fenofibrate (LDL cholesterol... 3

LDL cholesterol change in response to fe... 8

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (4)

Cell Cycle 590

Cell Cycle, Mitotic 488

M Phase 344

Mitotic Telophase/Cytokinesis 13

Protein-protein Interaction (1)

MOB3C

Gene RIF (3)

AA Sequence

MAAQAAAAAQAAAAQAAQAEAADSWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQ      1 - 70
LGSVLYHHTKNSEQARSHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQT     71 - 140
PYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTL    141 - 210
CGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLF    211 - 280
HWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVT    281 - 350
GHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVT    351 - 420
NLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSN    421 - 490
AEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHE    491 - 560
AAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL                     561 - 613
//

Text Mined References (17)

Summary
Details

	PMID	Year	Title

Tdark MAU2 chromatid cohesion factor homolog Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent

No data available

TINX Plot

Disease (1)

Expression

Synonym

Gene

Ortholog (11)

UniProt Keyword (11)

GO Function (2)

GO Component (5)

GO Process (2)

Compartment GO Term (31)

IMPC Phenotype (6)

MGI Phenotype (10)

GWAS Trait (9)

HCA RNA Cell Line (56)

Pathway (4)

Protein-protein Interaction (1)

Gene RIF (3)

AA Sequence

Text Mined References (17)

Tdark MAU2 chromatid cohesion factor homolog

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