Tbio SLC4A4 Electrogenic sodium bicarbonate cotransporter 1

Protein Summary

Description

Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Isoform 2: May have a higher activity than isoform 1. This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q9Y6R1
• C4B714
• O15153
• Q8NEJ2
• Q9H262
• Q9NRZ1
• Q9UIC0
• Q9UIC1
• Q9UP50
• Sodium bicarbonate cotransporter

Gene Name

• SLC4A4

Ensembl ID

• ENST00000264485
• ENSP00000264485
• ENSG00000080493
• ENST00000340595
• ENSP00000344272
• ENST00000351898
• ENSP00000307349
• ENST00000425175
• ENSP00000393557
• ENST00000512686
• ENSP00000422400
• ENST00000649996
• ENSP00000497468

Symbol

• NBC
• NBC1
• NBCE1
• KNBC
• NBC1
• NBC2
• pNBC
• HNBC1
• hhNMC
• kNBC1
• SLC4A5
• NBCe1-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
disease perturbation	0.87
molecular function	0.86
small molecule perturbation	0.84
histone modification site profile	0.79

Protein Classes

PANTHER Classes

Protein / ... / Cation Transporter / Electrogenic Sodium Bicarbonate Cotransporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc4 Family Of Bicarbonate Transporters / Sodium-dependent Hco3- Transporters / Electrogenic Sodium Bicarbonate Cotransporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.42   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.42   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0