Property Summary

NCBI Gene PubMed Count 15
PubMed Score 15.31
PubTator Score 8.67

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
Duchenne muscular dystrophy 602 4.65930563294796E-11
non-inflammatory breast cancer 208 2.17336330683961E-8
juvenile dermatomyositis 1189 3.67894401422536E-8
malignant mesothelioma 3163 1.08263044367326E-5
invasive ductal carcinoma 2950 4.8164980235323E-5
breast carcinoma 1614 9.8008919581234E-4
psoriasis 6685 0.00174143571609184
chronic kidney disease 90 0.00985525408084898
Endometriosis 535 0.0104586549509031
medulloblastoma, large-cell 6234 0.0114033900807442
osteosarcoma 7933 0.037630391328633

Expression

  Differential Expression (11)

Disease log2 FC p
malignant mesothelioma 2.300 0.000
psoriasis -1.100 0.002
osteosarcoma 3.136 0.038
medulloblastoma, large-cell 1.300 0.011
Duchenne muscular dystrophy 2.112 0.000
juvenile dermatomyositis 1.289 0.000
chronic kidney disease 1.600 0.010
breast carcinoma -1.800 0.001
invasive ductal carcinoma -3.304 0.000
Endometriosis -2.594 0.010
non-inflammatory breast cancer -3.500 0.000

Synonym

Accession Q9Y6Q1 D3DUY7 Q9UEQ1 Q9UJA8
Symbols CANPX
CAPNX
CalpM
DJ914P14.1

Gene

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Opossum OMA Inparanoid

Gene RIF (6)

PMID Text
21681744 syndecan-2 exerts its pro-apoptotic function through modulation of the endothelin-1/NFkappaB signaling and through downregulation of calpain-6.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20414141 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
18657900 results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis
18187620 Knockdown of calpain 6 (CAPN6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells

AA Sequence

MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISN      1 - 70
HQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLL     71 - 140
PTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEE    141 - 210
KYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMV    211 - 280
RLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGR    281 - 350
KELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI    351 - 420
IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEV    421 - 490
PVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVH    491 - 560
AIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISF    561 - 630
KVISSDDLTEL                                                               631 - 641
//

Text Mined References (16)

PMID Year Title
21681744 2012 Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20414141 2010 Family-based association study for bipolar affective disorder.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18657900 2008 Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.
17210638 2007 Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15772651 2005 The DNA sequence of the human X chromosome.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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