| Tbio | Roundabout homolog 1 |
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Comments
| Disease | Target Count |
|---|---|
| Adenocarcinoma | 115 |
| Autistic Disorder | 320 |
| Lung Neoplasms | 171 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2844 | 1.43791682271229E-12 |
| group 4 medulloblastoma | 1875 | 2.48250557606989E-9 |
| malignant mesothelioma | 3163 | 1.08907252444774E-7 |
| ulcerative colitis | 2087 | 1.76036706495157E-7 |
| pilocytic astrocytoma | 3086 | 2.8358601114683E-7 |
| cystic fibrosis | 1670 | 8.82744182186347E-7 |
| lung cancer | 4473 | 6.95501283850548E-6 |
| ovarian cancer | 8492 | 1.67807021215243E-5 |
| posterior fossa group B ependymoma | 1530 | 4.37291252589436E-5 |
| nasopharyngeal carcinoma | 1056 | 0.00688532120048643 |
| sarcoidosis | 368 | 0.00841304517699958 |
| active Crohn's disease | 918 | 0.0122661884147711 |
| pancreatic cancer | 2300 | 0.0143979748335958 |
| gastric carcinoma | 832 | 0.015526706726505 |
| primary pancreatic ductal adenocarcinoma | 1271 | 0.0166710854563836 |
| osteosarcoma | 7933 | 0.0316396284917463 |
| colon cancer | 1475 | 0.03207528802647 |
| Breast cancer | 3099 | 0.042476040417104 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -1.700 | 0.000 |
| osteosarcoma | 1.299 | 0.032 |
| posterior fossa group B ependymoma | -2.100 | 0.000 |
| cystic fibrosis | 3.108 | 0.000 |
| primary pancreatic ductal adenocarcinoma | 1.282 | 0.017 |
| colon cancer | 2.100 | 0.032 |
| lung cancer | 4.800 | 0.000 |
| active Crohn's disease | 2.638 | 0.012 |
| sarcoidosis | 1.200 | 0.008 |
| Breast cancer | 3.100 | 0.042 |
| group 4 medulloblastoma | -3.700 | 0.000 |
| pilocytic astrocytoma | 1.600 | 0.000 |
| nasopharyngeal carcinoma | 1.200 | 0.007 |
| lung carcinoma | 1.300 | 0.000 |
| gastric carcinoma | 1.800 | 0.016 |
| ulcerative colitis | 3.200 | 0.000 |
| ovarian cancer | -2.400 | 0.000 |
| pancreatic cancer | 1.300 | 0.014 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| PMID | Text |
|---|---|
| 26975850 | A SLIT2/ROBO1 signaling circuit as a key regulatory mechanism. |
| 26713366 | These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs. |
| 26608094 | ROBO1 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO1 produces anti-proliferative and pro-apoptotic effects in leukaemia cells. However, this effect was lost in ROBO mutants. |
| 26400100 | our findings indicated that Slit2/Robo1 axis possibly be regarded as a significant clinical parameter for predicting brain metastasis in breast cancer patients. |
| 26282852 | expression pattern in extravillous trophoblasts associated with the remodeling events of the tubal pregnancy |
| 26264936 | Significantly increased serum Slit2 levels and hepatic expression of Slit2 and Robo1 were observed in patients with liver fibrosis. |
| 26252416 | miR-29a markedly inhibits the protein expression of Robo1 in mesenchymal stem cells. |
| 26081620 | these studies demonstrate that miR-219-5p inhibited cancer cell growth and invasion by direct targeting ROBO1, implicating miR-219-5p as an attractive candidate for cancer therapy. |
| 26022159 | Robo1 promoted cell division cycle 42 (Cdc42) expression in HUVECs, and a distorted actin cytoskeleton in HUVECs was observed when Robo1 expression was suppressed. In conclusion, Robo1 promoted angiogenesis in HCC mediated by Cdc42. |
| 25955714 | miR29a inhibits cell migration and invasion in breast cancer cells, at least in part, by directly targeting Robo1. |
| More... |
MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRI 1 - 70 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 71 - 140 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP 141 - 210 LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 211 - 280 FKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 281 - 350 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 351 - 420 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK 421 - 490 DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 491 - 560 PSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 561 - 630 LFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQ 631 - 700 SQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKT 701 - 770 LEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 771 - 840 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWII 841 - 910 LMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTW 911 - 980 PNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEM 981 - 1050 KTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQN 1051 - 1120 KLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP 1121 - 1190 AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1191 - 1260 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEE 1261 - 1330 EDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTD 1331 - 1400 ADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGH 1401 - 1470 LRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQV 1471 - 1540 VDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSR 1541 - 1610 GSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1611 - 1651 //
| PMID | Year | Title |
|---|---|---|
| 26975850 | 2016 | Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness. |
| 26713366 | 2016 | Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4. |
| 26608094 | 2015 | Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes. |
| 26529257 | 2015 | Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression. |
| 26400100 | 2015 | Low Expression of Slit2 and Robo1 is Associated with Poor Prognosis and Brain-specific Metastasis of Breast Cancer Patients. |
| 26282852 | 2015 | Role of Slit2/Robo1 in trophoblast invasion and vascular remodeling during ectopic tubal pregnancy. |
| 26264936 | 2015 | Activation of Slit2-Robo1 signaling promotes liver fibrosis. |
| 26252416 | 2015 | MicroRNA-29a inhibits mesenchymal stem cell viability and proliferation by targeting Roundabout 1. |
| 26081620 | 2015 | MicroRNA-219-5p exerts tumor suppressor function by targeting ROBO1 in glioblastoma. |
| 26022159 | 2015 | Robo1 promotes angiogenesis in hepatocellular carcinoma through the Rho family of guanosine triphosphatases' signaling pathway. |
| More... |
