| Tbio | Roundabout homolog 1 |
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Adenocarcinoma | 122 | 0.0 | 0.0 |
| Autistic Disorder | 364 | 0.0 | 0.0 |
| Lung Neoplasms | 232 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.4e-12 |
| group 4 medulloblastoma | 1855 | 2.5e-09 |
| malignant mesothelioma | 3232 | 1.1e-07 |
| ulcerative colitis | 1819 | 1.8e-07 |
| Astrocytoma, Pilocytic | 3081 | 4.0e-07 |
| cystic fibrosis | 1696 | 8.8e-07 |
| lung cancer | 4740 | 7.0e-06 |
| ovarian cancer | 8520 | 1.7e-05 |
| ependymoma | 4679 | 3.6e-03 |
| nasopharyngeal carcinoma | 1058 | 6.9e-03 |
| sarcoidosis | 370 | 8.4e-03 |
| active Crohn's disease | 922 | 1.2e-02 |
| pancreatic cancer | 2398 | 1.4e-02 |
| gastric carcinoma | 807 | 1.6e-02 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.7e-02 |
| osteosarcoma | 7950 | 3.2e-02 |
| colon cancer | 1478 | 3.2e-02 |
| Breast cancer | 3578 | 4.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 2.638 | 1.2e-02 |
| Astrocytoma, Pilocytic | 1.600 | 4.0e-07 |
| Breast cancer | 3.100 | 4.2e-02 |
| colon cancer | 2.100 | 3.2e-02 |
| cystic fibrosis | 3.108 | 8.8e-07 |
| ependymoma | -1.500 | 3.6e-03 |
| gastric carcinoma | 1.800 | 1.6e-02 |
| group 4 medulloblastoma | -3.700 | 2.5e-09 |
| lung cancer | 4.800 | 7.0e-06 |
| lung carcinoma | 1.300 | 1.4e-12 |
| malignant mesothelioma | -1.700 | 1.1e-07 |
| nasopharyngeal carcinoma | 1.200 | 6.9e-03 |
| osteosarcoma | 1.299 | 3.2e-02 |
| ovarian cancer | -2.400 | 1.7e-05 |
| pancreatic cancer | 1.300 | 1.4e-02 |
| primary pancreatic ductal adenocarcinoma | 1.282 | 1.7e-02 |
| sarcoidosis | 1.200 | 8.4e-03 |
| ulcerative colitis | 3.200 | 1.8e-07 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| OMA EggNOG |
MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRI 1 - 70 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP 71 - 140 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP 141 - 210 LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 211 - 280 FKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 281 - 350 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 351 - 420 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK 421 - 490 DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 491 - 560 PSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 561 - 630 LFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQ 631 - 700 SQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKT 701 - 770 LEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 771 - 840 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWII 841 - 910 LMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTW 911 - 980 PNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEM 981 - 1050 KTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQN 1051 - 1120 KLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP 1121 - 1190 AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1191 - 1260 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEE 1261 - 1330 EDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTD 1331 - 1400 ADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGH 1401 - 1470 LRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQV 1471 - 1540 VDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSR 1541 - 1610 GSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1611 - 1651 //
