Tclin NDUFB9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q9Y6M9
• B2R8M6
• Q9UQE8

Gene Name

• NDUFB9

Ensembl ID

• ENST00000276689
• ENSP00000276689
• ENSG00000147684

Symbol

• LYRM3
• UQOR22
• B22
• LYRM3
• CI-B22
• UQOR22
• MC1DN24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.99
disease perturbation	0.96
histone modification site profile	0.89
transcription factor perturbation	0.88
cellular component	0.79

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 9

DTO Classes

Protein / Enzyme / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.54   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.54   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1