Property Summary

NCBI Gene PubMed Count 259
Grant Count 53
R01 Count 50
Funding $5,285,796.91
PubMed Score 533.46
PubTator Score 531.88

Knowledge Summary

Patent

No data available

Protein-protein Interaction (9)

Gene RIF (282)

PMID Text
27455553 The HEK-293 cell lines stably expressing human OATP1B1-wild and variant (HEK-OATP1B1, *1b and *15) are potential models to study drug transport in vitro
26607661 SLCO1B1 variants are strongly associated with an increased risk of enalapril-induced cough.
26562723 TM11 of OATP1B1 may face the substrate interaction pocket.
26482301 The SLCO1B1 rs1104581 polymorphism, weight, and gender appear to play important roles for rifabutin efficiency in African HIV-Infected patients with tuberculosis.
26474710 OATP1B1- and OATP1B3-humanized mice can be used as in vivo tools to assess and possibly predict clinically relevant DDIs.
26409184 Results identified interethnic differences of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes in Korean population compared with other ethnic groups.
26383540 transport of CPR I mediated by OATP1B1 and OATP1B3 and the transport of CPR III mediated by OATPs 1B1, 1B3 and 2B1 is time-dependent, can be saturated and inhibited
26380303 Patients with better muscle function had the highest concentration of CK, IL-1, and TNF-a compared with less muscle function
26376374 T521C polymorphism associated with an increased risk of statin-related myopathy, especially in individuals receiving simvastatin [review]
26373210 this extensive analysis of the effect of SLCO1B1 polymorphisms on the pharmacokinetic profile of atorvastatin showed that SNPs may affect the inter-individual response to atorvastatin
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AA Sequence

MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFID      1 - 70
GSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLS     71 - 140
TCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLG    141 - 210
ILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLP    211 - 280
QTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVS    281 - 350
SYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS    351 - 420
FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCK    421 - 490
SSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIV    491 - 560
KIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSS    561 - 630
MLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC             631 - 691
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Publication (261)

PMID Year Title
27455553 2016 Construction of HEK293 cells stably expressing wild-type organic anion transporting polypeptide 1B1 (OATP1B1*1a) and variant OATP1B1*1b and OATP1B1*15.
26607661 2015 SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril)-Induced Cough: a Pharmacogenetic Study.
26562723 2015 Amino Acid Residues in the Putative Transmembrane Domain 11 of Human Organic Anion Transporting Polypeptide 1B1 Dictate Transporter Substrate Binding, Stability, and Trafficking.
26482301 2015 Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis.
26474710 2015 Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.
26409184 2015 Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.
26383540 2016 Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.
26380303 2015 Systemic Inflammation in Duchenne Muscular Dystrophy: Association with Muscle Function and Nutritional Status.
26376374 2015 Association Between SLCO1B1 Gene T521C Polymorphism and Statin-Related Myopathy Risk: A Meta-Analysis of Case-Control Studies.
26373210 2015 Effects of single nucleotide polymorphisms and haplotypes of the SLCO1B1 gene on the pharmacokinetic profile of atorvastatin in healthy Macedonian volunteers.
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