Property Summary

NCBI Gene PubMed Count 29
PubMed Score 13.13
PubTator Score 13.03

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
breast carcinoma 1614 5.13544114350373E-16
ovarian cancer 8492 7.51368837210513E-15
juvenile dermatomyositis 1189 1.60409842786484E-11
non-small cell lung cancer 2798 8.04720968290569E-9
osteosarcoma 7933 1.31227505696971E-7
Duchenne muscular dystrophy 602 4.34763267206388E-7
malignant mesothelioma 3163 9.6545904838238E-7
Breast cancer 3099 1.2065676031597E-6
Amyotrophic Lateral Sclerosis 432 2.2477367198117E-6
psoriasis 6685 9.42973816085327E-6
lung cancer 4473 2.77771087879183E-5
acute quadriplegic myopathy 1157 3.35088096015384E-5
cystic fibrosis 1670 7.69205719771398E-5
primitive neuroectodermal tumor 3031 9.30652425431375E-5
lung adenocarcinoma 2714 2.78057035698611E-4
oligodendroglioma 2849 4.10884077392352E-4
ependymoma 2514 4.91521837854816E-4
pilocytic astrocytoma 3086 9.17595950032836E-4
group 4 medulloblastoma 1875 0.00137667239766205
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00143429225648392
atypical teratoid / rhabdoid tumor 4369 0.00201375314954714
colon cancer 1475 0.00213777162536705
tuberculosis 1563 0.00288322176661195
ulcerative colitis 2087 0.00297134275550435
dermatomyositis 967 0.00335915428596938
Pick disease 1893 0.00531741576974573
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00571072898159135
medulloblastoma, large-cell 6234 0.00660303196984068
astrocytic glioma 2241 0.00683354998105758
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00754510003062685
hepatocellular carcinoma 550 0.00800564757930255
pancreatic cancer 2300 0.0111958338181417
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0146622539018846
sarcoidosis 368 0.014844717809966
Pneumonia 133 0.0152404836539739
progressive supranuclear palsy 674 0.0158292033789119
pediatric high grade glioma 2712 0.0304669947191529
gastric carcinoma 832 0.0361188658318408
glioblastoma 5572 0.0402331050350676
Gaucher disease type 1 171 0.0458875561072954
Disease Target Count Z-score Confidence
Dental caries 67 0.0 1.0
Myeloid Leukemia 19 0.0 2.0



Accession Q9Y6I7 Q9NRB1 Q9UBH9 Q9UG25 Q9UNN6 Q9Y656 WSB-1
Symbols SWIP1


  Ortholog (11)

Species Source
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (10)

26545811 WSB1 up-regulates the expression of HIF-1alpha's target genes and promotes cancer invasion and metastasis through its effect on pVHL
26424695 Our findings show how WSB1 regulates key steps of the metastatic cascade in hypoxia-driven osteosarcoma
24441107 combination of WSB1(3) silencing together with WSB1 isoforms 1+2 silencing in NB cells showed reduced growth, enhanced apoptosis rate, and increased sensitivity to chemotherapeutic agents, specifically related to low expression of WSB1
23792163 HIF1 has a role in regulating WSB-1 expression, which promotes hypoxia-induced chemoresistance in hepatocellular carcinoma cells
20487506 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
18978678 Observational study of gene-disease association. (HuGE Navigator)
18575577 Data on WSB1 regulation support the hypothesis that activation of stress-response mechanisms helps cancer cells establishing metastases and suggest relevance to cancer development of other genes overexpressed in xenografts
18093972 the regulatory mechanisms by which HIPK2 is maintained at a low level, by WSB-1 in cells under normal conditions, and stabilized by genotoxic stresses.
16804916 WSB1 shows strong correlations between expression level and copy number, and also enhances the prognostic prediction when combined with other current prognostic factors in neuroblastoma.
15965468 WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2).

AA Sequence


Text Mined References (31)

PMID Year Title
26545811 2015 WSB1 promotes tumor metastasis by inducing pVHL degradation.
26424695 2015 Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells.
24441107 2014 Potential role of WSB1 isoforms in growth and survival of neuroblastoma cells.
23792163 2013 HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells.
23064961 2013 GWAS of dental caries patterns in the permanent dentition.
21540461 2011 A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
20487506 2010 A whole genome association study of mother-to-child transmission of HIV in Malawi.
19028597 2009 Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.
18978678 2008 Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
18575577 2008 The WSB1 gene is involved in pancreatic cancer progression.