Property Summary

NCBI Gene PubMed Count 28
PubMed Score 30.44
PubTator Score 27.77

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
non primary Sjogren syndrome sicca 840 0.0177747802367708
Disease Target Count Z-score Confidence
Duodenum adenocarcinoma 4 3.584 1.8


  Differential Expression (1)

Disease log2 FC p
non primary Sjogren syndrome sicca 1.300 0.018


Accession Q9Y6I3 Q86ST3 Q9HA18




  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (9)

26975582 Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1.
26204806 intrinsically disordered domains are highly potent drivers of membrane curvature
25871009 Epsins are required for Dishevelled stability and Wnt signalling activation in colon cancer development.
21965661 AP-2 and epsin-1 are both required to promote efficient internalization of activated PAR1 and recognize discrete receptor sorting signals
19704019 Results show that epsin 1, an endocytic adapter protein, regulates mitotic membrane morphology and spindle integrity in HeLa cells.
19054389 epsin 1 promotes endocytosis of the ubiquitinated EGF receptor
18375383 A synthetic peptide containing the Epsin-1-(470-499) sequence could effectively block entry of HIV-1 virions into SupT1 T cells via the endocytosis pathway
15694383 Together, these data provide evidence that CHIP functions to ubiquitylate the endocytic protein Epsin.
12353027 An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations

AA Sequence

MMPPGPPAPNTNPFLL                                                          561 - 576

Text Mined References (41)

PMID Year Title
26975582 2016 Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3.
26204806 2015 Intrinsically disordered proteins drive membrane curvature.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25871009 2015 Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23377640 2013 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21965661 2011 Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19704019 2009 A requirement for epsin in mitotic membrane and spindle organization.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19367720 2008 Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
19054389 2009 Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18199683 2008 The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16964243 2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
16903783 2006 Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.
16516836 2006 Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15962011 2005 Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.
15694383 2005 The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057824 2004 The DNA sequence and biology of human chromosome 19.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12836669 2002 Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin.
12775724 2003 RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12353027 2002 Curvature of clathrin-coated pits driven by epsin.
12218189 2002 Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.
11382783 2001 Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller.
10791968 2000 Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF).
10764745 2000 Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.
10692452 2000 Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites.
10567358 1999 The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.
10557078 1999 Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis.
9723620 1998 Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.
9422736 1998 Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.