Tbio GJA3 Gap junction alpha-3 protein

Protein Summary

Description

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q9Y6H8
• Q0VAB7
• Q9H537

Gene Name

• GJA3

Ensembl ID

• ENST00000241125
• ENSP00000241125
• ENSG00000121743

Symbol

• CX46
• CZP3
• CTRCT14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.75
protein domain	0.73
cell type or tissue	0.68
tissue sample	0.64
PubMedID	0.59

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Gap Junction / Gap Junction Alpha-3 Protein

DTO Classes

Protein / Cell-cell Junction / Gap Junction / Gap Junction Alpha-3 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.67   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.67   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0