Property Summary

NCBI Gene PubMed Count 10
PubMed Score 6.42
PubTator Score 16.32

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
ovarian cancer 8492 2.77524646506154E-4
dermatomyositis 967 0.00116974043479467
Breast cancer 3099 0.0279698163743824
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0498290881256737
Disease Target Count Z-score Confidence
Yellow fever 14 3.863 1.9


  Differential Expression (4)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -1.651 0.050
Breast cancer 2.500 0.028
ovarian cancer 2.500 0.000
dermatomyositis 1.100 0.001


Accession Q9Y6A9 B3KNF8 Q9BVW1
Symbols SPC1


PANTHER Protein Class (1)

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque EggNOG Inparanoid
Opossum EggNOG Inparanoid
Chicken EggNOG Inparanoid
Anole lizard EggNOG Inparanoid
Xenopus EggNOG Inparanoid
C. elegans EggNOG Inparanoid
Fruitfly EggNOG Inparanoid

 GO Function (1)

Gene RIF (2)

24886551 cis-acting regulatory polymorphisms acting on GNL3 and SPCS1 contribute to the OA association signal at chromosome 3p21, and these genes therefore merit further investigation.
24009510 SPCS1 plays a key role in the formation of the membrane-associated NS2-E2 complex via its interaction with NS2 and E2, which leads to a coordinating interaction between the structural and non-structural proteins

AA Sequence

RRHPLKWLPVQESSTDDKKPGERKIKRHAKNN                                           71 - 102

Text Mined References (15)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25056061 2014 Biological insights from 108 schizophrenia-associated genetic loci.
24886551 2014 Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1.
24023390 2013 Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.
24009510 2013 Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2.
23974872 2013 Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21926972 2011 Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
21269460 2011 Initial characterization of the human central proteome.
16641997 2006 The DNA sequence, annotation and analysis of human chromosome 3.