POMT1
Protein O-mannosyl-transferase 1
Protein Summary
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
- ENST00000341012
- ENSP00000343034
- ENSG00000130714
- ENST00000372228
- ENSP00000361302
- ENST00000402686
- ENSP00000385797
- ENST00000404875
- ENSP00000384531
- ENST00000423007
- ENSP00000404119
- RT
- LGMD2K
- MDDGA1
- MDDGB1
- MDDGC1
- LGMDR11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
phenotype | 0.75 | ||
transcription factor binding site profile | 0.74 | ||
cellular component | 0.72 | ||
histone modification site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.04 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.04 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0