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Tdark 28S ribosomal protein S18b, mitochondrial

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 18
PubMed Score 4.10
PubTator Score 1.39

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Disease Progression 136 0.0 0.0
Stomach Neoplasms 300 0.0 0.0

Expression

  Differential Expression (5)

Disease log2 FC p
intraductal papillary-mucinous neoplasm ... -1.200 1.7e-03
lung cancer 1.300 1.0e-03
malignant mesothelioma 1.100 1.9e-06
ovarian cancer 1.200 1.1e-02
psoriasis -1.200 1.1e-03

Synonym

Accession Q9Y676 A6NDQ0 Q659G4 Q9BS27 MRP-S18-b
Symbols PTD017
S18amt
C6orf14
HSPC183
MRPS18-2
HumanS18a
MRP-S18-2

Gene

MRPS18B

PDB

3J9M  

  Ortholog (1)

Species Source Disease
Chimp OMA Inparanoid

 UniProt Keyword (9)

 GO Function (1)

 GO Component (5)

 GO Process (4)

 Compartment GO Term (46)

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 HCA RNA Cell Line (56)

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Pathway (7)

Protein-protein Interaction (47)

MRPS9   MRPS26   STRBP   KIAA0391   PTCD3   METTL17   PTCD1   TOP3A   MRPS23   MRPS27   TRUB2   MRPS6   MRPS10   MRPS34   DAP3   NOA1   MRPS31   MRPS18C   MRPS5   MRPS7   MRPS22   DDX55   MTERF3   P3H3   MRPS15   MRPS35   MRPS25   NGRN   SUPV3L1   SIRT3   MRPS2   DHX36   MRPS33   MRPS11   GNL2   MRPS24   DNAJC21   MRPS17   POLRMT   MRPS14   MCAT   MRPS16   WDR33   NDUFAF7   MRPS28   POLG   MRPS21  

Gene RIF (6)

AA Sequence 

MAASVLNTVLRRLPMLSLFRGSHRVQVPLQTLCTKAPSEEDSLSSVPISPYKDEPWKYLESEEYQERYGS      1 - 70
RPVWADYRRNHKGGVPPQRTRKTCIRRNKVVGNPCPICRDHKLHVDFRNVKLLEQFVCAHTGIIFYAPYT     71 - 140
GVCVKQHKRLTQAIQKARDHGLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYPWYNWKQPPE    141 - 210
RELSRLRRLYQGHLQEESGPPPESMPKMPPRTPAEASSTGQTGPQSAL                          211 - 258
//

Text Mined References (25)

PMID Year Title