| Tdark | 28S ribosomal protein S18b, mitochondrial |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Disease Progression | 136 | 0.0 | 0.0 |
| Stomach Neoplasms | 300 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 1.9e-06 |
| lung cancer | 4740 | 1.0e-03 |
| psoriasis | 6694 | 1.1e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.7e-03 |
| ovarian cancer | 8520 | 1.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous neoplasm ... | -1.200 | 1.7e-03 |
| lung cancer | 1.300 | 1.0e-03 |
| malignant mesothelioma | 1.100 | 1.9e-06 |
| ovarian cancer | 1.200 | 1.1e-02 |
| psoriasis | -1.200 | 1.1e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
MRPS9
MRPS26
STRBP
KIAA0391
PTCD3
METTL17
PTCD1
TOP3A
MRPS23
MRPS27
TRUB2
MRPS6
MRPS10
MRPS34
DAP3
NOA1
MRPS31
MRPS18C
MRPS5
MRPS7
MRPS22
DDX55
MTERF3
P3H3
MRPS15
MRPS35
MRPS25
NGRN
SUPV3L1
SIRT3
MRPS2
DHX36
MRPS33
MRPS11
GNL2
MRPS24
DNAJC21
MRPS17
POLRMT
MRPS14
MCAT
MRPS16
WDR33
NDUFAF7
MRPS28
POLG
MRPS21
MAASVLNTVLRRLPMLSLFRGSHRVQVPLQTLCTKAPSEEDSLSSVPISPYKDEPWKYLESEEYQERYGS 1 - 70 RPVWADYRRNHKGGVPPQRTRKTCIRRNKVVGNPCPICRDHKLHVDFRNVKLLEQFVCAHTGIIFYAPYT 71 - 140 GVCVKQHKRLTQAIQKARDHGLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYPWYNWKQPPE 141 - 210 RELSRLRRLYQGHLQEESGPPPESMPKMPPRTPAEASSTGQTGPQSAL 211 - 258 //
