Property Summary

NCBI Gene PubMed Count 25
PubMed Score 99.01
PubTator Score 3749.06

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
juvenile dermatomyositis 1189 7.3327987010528E-13
osteosarcoma 7933 2.38681644844926E-9
Duchenne muscular dystrophy 602 2.47920200475276E-8
ovarian cancer 8492 5.60522483439824E-6
Amyotrophic Lateral Sclerosis 432 9.7049100701522E-5
glioblastoma 5572 2.78646827266151E-4
limb girdle muscular dystrophy 2A 156 9.57200318657403E-4
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00189216748284521
primary pancreatic ductal adenocarcinoma 1271 0.0019788049052245
acute quadriplegic myopathy 1157 0.00205016622835405
group 4 medulloblastoma 1875 0.00234034584819883
pancreatic cancer 2300 0.00534778089445666
Becker muscular dystrophy 187 0.0105538663580349
ependymoma 2514 0.0232633397226519
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0356104250979449
cystic fibrosis and chronic rhinosinusitis 213 0.0412404125886044
acute myeloid leukemia 785 0.0455262794018982



Accession Q9Y657 A8K0X6 B3KRQ4 Q7KZJ8 Q9GZT2 Q9H0N7
Symbols SPIN



2NS2   4H75   4MZF   4MZG   4MZH  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Pathway (1)

Gene RIF (11)

25749382 High SPIN1 expression is associated with liposarcoma.
24589551 Spindlin1 activates Wnt/beta-catenin signaling downstream from protein arginine methyltransferase 2 (PRMT2) and the MLL complex, which together are capable of generating a specific H3 "K4me3-R8me2a" pattern.
23077255 the histone sequence is recognized in a distinct manner involving the amino terminus and a pair of arginine residues of histone H3, and disruption of the binding impaired stimulation of pre-RNA expression by Spindlin1
22258766 SPINDLIN1, which may be a novel substrate of the Aurora-A kinase, promotes cancer cell growth through WNT/TCF-4 signaling activation.
21960006 Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of ribosomal RNA genes.
21044367 Observational study of gene-disease association. (HuGE Navigator)
18543248 Excess spindlin1 protein may be detrimental for spindle microtubule organization, chromosomal stability and can potentially contribute to the development of cancer.
18201843 SPINDLIN1 is an important gene for mammalian mitotic chromosome functions, and disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis
17082182 analysis of human spindlin1 tudor-like domains for cell cycle regulation
16472086 recombinant human spindlin1 has been overexpressed in Escherichia coli BL21, purified and crystallized using the hanging-drop vapour-diffusion method

AA Sequence


Text Mined References (29)

PMID Year Title
25749382 2015 The histone code reader SPIN1 controls RET signaling in liposarcoma.
25277244 2014 The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.
24589551 2014 Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23077255 2012 Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22258766 2012 SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling.
21960006 2011 Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes.
21044367 2010 An integrative method for scoring candidate genes from association studies: application to warfarin dosing.
21029866 2010 Nucleosome-interacting proteins regulated by DNA and histone methylation.