Tbio SOX21 Transcription factor SOX-21

Protein Summary

Description

May play a role as an activator of transcription of OPRM1. SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9Y651
• P35715
• Q15504
• Q5TBS1

Gene Name

• SOX21

Ensembl ID

• ENST00000376945
• ENSP00000366144
• ENSG00000125285

Symbol

• SOX25
• SOXA
• SOX25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.75
gene perturbation	0.61
transcription factor binding site profile	0.59
cell type or tissue	0.58
microRNA	0.57

Protein Classes

PANTHER Classes

Protein / ... / Hmg Box Transcription Factor / Transcription Factor Sox-21

DTO Classes

Protein / Transcription Factor / Hmg Box Transcription Factor / Transcription Factor Sox-21

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.3   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.3   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0