Tbio GPR45 Probable G-protein coupled receptor 45

Protein Summary

Description

Orphan receptor. May play a role in brain function. This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5Y3
• Q6NWS4
• Q6NXU6

Gene Name

• GPR45

Ensembl ID

• ENST00000258456
• ENSP00000258456
• ENSG00000135973

Symbol

• PSP24
• PSP24A
• PSP24(ALPHA)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.65
cell type or tissue	0.63
tissue	0.56
virus perturbation	0.45
cell line	0.41

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Probable G-protein Coupled Receptor 45

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Probable G-protein Coupled Receptor 45

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.43   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.43   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0