Protein Summary
Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin. The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]
- ENST00000261292
- ENSP00000261292
- ENSG00000101670
- ENST00000580036
- ENSP00000462420
- EL
- EDL
- PRO719
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 1 | ||
protein domain | 0.92 | ||
cell type or tissue | 0.84 | ||
histone modification site profile | 0.82 | ||
gene perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 267 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 928 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 267 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 928 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 545
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1