Property Summary

NCBI Gene PubMed Count 96
PubMed Score 130.26
PubTator Score 136.38

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 2.60933331384424E-49
Breast cancer 3099 7.8376517715369E-49
breast carcinoma 1614 1.85874391050748E-22
lung adenocarcinoma 2714 2.42117240355074E-18
psoriasis 6685 3.43811249755151E-16
non-small cell lung cancer 2798 9.55439281668202E-16
medulloblastoma 1524 1.11560423690463E-8
glioblastoma 5572 1.35678387322812E-5
adult high grade glioma 2148 3.12107810334398E-5
interstitial cystitis 2299 4.02281890590516E-5
primitive neuroectodermal tumor 3031 6.83548295318985E-5
Atopic dermatitis 944 1.15001940844478E-4
cutaneous lupus erythematosus 1056 5.79426733755101E-4
colon cancer 1475 6.26909061986569E-4
subependymal giant cell astrocytoma 2287 9.64270084714121E-4
astrocytic glioma 2241 0.00334046602397485
posterior fossa group B ependymoma 1530 0.00788199588523113
pituitary cancer 1972 0.0128234991244986
medulloblastoma, large-cell 6234 0.0138989540760644
pilocytic astrocytoma 3086 0.0188112937835591
invasive ductal carcinoma 2950 0.0355997949864917
oligodendroglioma 2849 0.0407072640484099
Disease Target Count Z-score Confidence
Cancer 2346 4.18 2.1
Pleomorphic adenoma 18 3.513 1.8


  Differential Expression (22)

Disease log2 FC p
astrocytic glioma -4.600 0.003
oligodendroglioma -3.800 0.041
psoriasis -4.400 0.000
cutaneous lupus erythematosus -3.200 0.001
glioblastoma -5.200 0.000
medulloblastoma -5.800 0.000
medulloblastoma, large-cell -4.000 0.014
primitive neuroectodermal tumor -4.600 0.000
Atopic dermatitis -4.000 0.000
non-small cell lung cancer -4.267 0.000
colon cancer -1.300 0.001
interstitial cystitis -5.000 0.000
lung adenocarcinoma -5.400 0.000
adult high grade glioma -5.000 0.000
pilocytic astrocytoma -2.200 0.019
posterior fossa group B ependymoma -2.500 0.008
subependymal giant cell astrocytoma -4.349 0.001
Breast cancer -5.200 0.000
lung carcinoma -5.700 0.000
breast carcinoma -3.500 0.000
invasive ductal carcinoma -1.300 0.036
pituitary cancer -1.900 0.013


Accession Q9Y5W5 Q6UXI1 Q8WVG4 WIF-1
Symbols WIF-1



2D3J   2YGN   2YGO   2YGP   2YGQ  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA EggNOG Inparanoid
Platypus OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
Fruitfly EggNOG Inparanoid

Gene RIF (83)

26405993 WIF-1 down-regulation may promote tumor cells invasion and metastasis in salivary gland adenoid cystic carcinoma.
26352791 Results provide evidence that WIF1 is frequently methylated in oral squamous cell carcinoma (OSCC), but not in oral submucous fibrosis tissues, which results in reduced expression. This epigenetic biomarker can be used for the early detection of OSCC.
26342861 Data show that the WIF domain of Wnt Inhibitory Factor 1 (WIF1) is bound by C-terminal domains of Wnt proteins Wnt5a and Wnt7a at two sites.
25918249 WIF1 has a role in breast neoplasms: its inhibition significantly relieves the cancer stem cell-limiting effects of dietary compound isoliquiritigenin
25772239 Loss of WIF1 enhances the migratory potential of glioblastoma through WNT5A that activates the WNT/Ca(2+) pathway and MALAT1.
25681036 miR-603 regulates glioma development via Wnt-beta-cateninn signaling pathway and its WIF1 and CTNNBIP1 targets.
25487617 Further evaluation of the methylation of DACH1, DKK1, and WIF1 in a clinical patient group confirmed the frequent methylation of WIF1 and intermediate or low frequency of methylation of DACH1 or DKK1, respectively.
25142166 Altered expression of genes associated with telomere maintenance and cell function of human vascular endothelial cell at elevated temperature.
25107489 Aberrant methylation of APC gene was statistically significant associated with age over 50, DDK3 with male, SFRP4, WIF1, and WNT5a with increasing tumor stage SFRP4 and WIF1 with tumor differentiation and SFRP2 and SFRP5 with histological type
25025467 detection of methylated Wif-1 in either S or U has a higher performance accuracy compared to guaiac FOBT for advanced colorectal neoplasia screening

AA Sequence

PAGAQLRQHTPSLKKAEERRDPPESNYIW                                             351 - 379

Text Mined References (96)

PMID Year Title
26405993 2015 Aberrant Wnt-1/beta-catenin signaling and WIF-1 deficiency are important events which promote tumor cell invasion and metastasis in salivary gland adenoid cystic carcinoma.
26352791 2015 Expression and promoter methylation of Wnt inhibitory factor-1 in the development of oral submucous fibrosis.
26342861 2015 Wnts grasp the WIF domain of Wnt Inhibitory Factor 1 at two distinct binding sites.
25918249 2015 Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation.
25772239 2016 WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.
25681036 2015 miR-603 promotes glioma cell growth via Wnt/?-catenin pathway by inhibiting WIF1 and CTNNBIP1.
25487617 2015 The negative regulators of Wnt pathway-DACH1, DKK1, and WIF1 are methylated in oral and oropharyngeal cancer and WIF1 methylation predicts shorter survival.
25416956 2014 A proteome-scale map of the human interactome network.
25142166 2014 Altered expression of genes associated with telomere maintenance and cell function of human vascular endothelial cell at elevated temperature.
25107489 2014 Promoter methylation analysis of WNT/?-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer.