Tbio DMRT2 Doublesex- and mab-3-related transcription factor 2

Protein Summary

Description

Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q9Y5R5
• B1ANC0
• B9EGJ1
• Q9NPG6
• Q9NQR6

Gene Name

• DMRT2

Ensembl ID

• ENST00000259622
• ENSP00000259622
• ENSG00000173253
• ENST00000358146
• ENSP00000350865
• ENST00000382251
• ENSP00000371686
• ENST00000382255
• ENSP00000371690
• ENST00000412350
• ENSP00000397494
• ENST00000635183
• ENSP00000489226

Symbol

• DSXL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
gene perturbation	0.71
cell type or tissue	0.64
PubMedID	0.64
cell line	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.63   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.63   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0