Property Summary

NCBI Gene PubMed Count 6
PubMed Score 17.16
PubTator Score 2.60

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
tuberculosis 1563 8.47772984944623E-7
ovarian cancer 8492 2.73577739988621E-5
medulloblastoma, large-cell 6234 6.51593295509099E-5
osteosarcoma 7933 1.02718723338723E-4
psoriasis 6685 2.35849918151204E-4
Disease Target Count Z-score Confidence
Leptospirosis 17 4.512 2.3

Expression

  Differential Expression (5)

Disease log2 FC p
psoriasis 1.300 0.000
osteosarcoma -1.301 0.000
medulloblastoma, large-cell 1.100 0.000
tuberculosis 1.300 0.000
ovarian cancer 1.400 0.000

Synonym

Accession Q9Y5R4
Symbols HEMK
MTQ1

Gene

  Ortholog (10)

Gene RIF (2)

PMID Text
20877624 Observational study of gene-disease association. (HuGE Navigator)
18541145 Human mitochondrial methyltransferase, HMPrmC, which methylates the glutamine residue in the GGQ tripeptide motif of HMRF1L, was identified.

AA Sequence

MELWGRMLWALLSGPGRRGSTRGWAFSSWQPQPPLAGLSSAIELVSHWTGVFEKRGIPEARESSEYIVAH      1 - 70
VLGAKTFQSLRPALWTQPLTSQQLQCIRELSSRRLQRMPVQYILGEWDFQGLSLRMVPPVFIPRPETEEL     71 - 140
VEWVLEEVAQRSHAVGSPGSPLILEVGCGSGAISLSLLSQLPQSRVIAVDKREAAISLTHENAQRLRLQD    141 - 210
RIWIIHLDMTSERSWTHLPWGPMDLIVSNPPYVFHQDMEQLAPEIRSYEDPAALDGGEEGMDIITHILAL    211 - 280
APRLLKDSGSIFLEVDPRHPELVSSWLQSRPDLYLNLVAVRRDFCGRPRFLHIRRSGP                281 - 338
//

Text Mined References (6)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
18541145 2008 The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10690633 1999 Is the HemK family of putative S-adenosylmethionine-dependent methyltransferases a "missing" zeta subfamily of adenine methyltransferases? A hypothesis.