Tbio INSL5 Insulin-like peptide INSL5

Protein Summary

Description

May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor. The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5Q6
• Q3MIY4
• Q5VYD8
• Insulin-like peptide 5

Gene Name

• INSL5

Ensembl ID

• ENST00000304526
• ENSP00000302724
• ENSG00000172410

Symbol

• PRO182
• UNQ156

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.73
pathway	0.5
tissue sample	0.49
cell line	0.46
cell type or tissue	0.44

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.5   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.5   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0