Tdark LENEP Lens epithelial cell protein LEP503

Protein Summary

Description

May play a role in lens epithelial cell differentiation. The ocular lens is a tissue of epithelial origin and devoid of blood vessels and nerves. Cells of the lens epithelium are responsible for the growth and maintenance of the lens through mitosis, protein synthesis, and active transport of ions and metabolites across the lens capsule. Lens epithelial protein is expressed exclusively in lens epithelial cells and may play a role in cell differentiation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5L5
• B5BUM1
• Q5T1A4

Gene Name

• LENEP

Ensembl ID

• ENST00000368427
• ENSP00000357412
• ENSG00000163352
• ENST00000392487
• ENSP00000376278

Symbol

• LEP503
• LEP503

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.59
small molecule perturbation	0.51
disease perturbation	0.49
transcription factor binding site profile	0.49
cell line	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0