Protein Summary
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critica ...more
- ENST00000378132
- ENSP00000367372
- ENSG00000204969
- ENST00000520672
- ENSP00000430584
- ENST00000526136
- ENSP00000431748
- PCDH-ALPHA2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
microRNA | 0.71 | ||
tissue sample | 0.63 | ||
protein domain | 0.58 | ||
cell line | 0.56 | ||
cell type or tissue | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.99 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 113 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.99 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 113 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0