Tbio MAB21L2 Protein mab-21-like 2

Protein Summary

Description

Required for several aspects of embryonic development including normal development of the eye. This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y586
• B3KP37
• Q9HBA7

Gene Name

• MAB21L2

Ensembl ID

• ENST00000317605
• ENSP00000324701
• ENSG00000181541

Symbol

• MCOPS14
• MCSKS14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.51
histone modification site profile	0.51
PubMedID	0.47
transcription factor	0.44
microRNA	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.32   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.32   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0