LRP12
Low-density lipoprotein receptor-related protein 12
Protein Summary
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
- ENST00000276654
- ENSP00000276654
- ENSG00000147650
- ENST00000424843
- ENSP00000399148
- ST7
- ST7
- MIG13A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.82 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.7 | ||
small molecule perturbation | 0.6 | ||
cell line | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.7 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.7 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0