You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POLR3H
DNA-directed RNA polymerase III subunit RPC8

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337566
  • ENSP00000337627
  • ENSG00000100413
  • ENST00000355209
  • ENSP00000347345
  • ENST00000396504
  • ENSP00000379761
  • ENST00000407461
  • ENSP00000385315

Symbol
  • KIAA1665
  • RPC8
  • RPC8
  • RPC22.9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
histone modification site profile
0.69
transcription factor binding site profile
0.66
microRNA
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0