MAP4K5
Mitogen-activated protein kinase kinase kinase kinase 5
Protein Summary
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
- ENST00000013125
- ENSP00000013125
- ENSG00000012983
- KHS
- GCKR
- KHS1
- MAPKKKK5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
protein domain | 0.85 | ||
small molecule | 0.8 | ||
transcription factor binding site profile | 0.78 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.53 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.53 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 52
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3