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Tbio
RIPOR2
Rho family-interacting cell polarization regulator 2

Protein Summary
Description
Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:24687993, PubMed:23241886, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). Isoform 2: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259698
  • ENSP00000259698
  • ENSG00000111913
  • ENST00000378023
  • ENSP00000367262
  • ENST00000613507
  • ENSP00000482957
  • ENST00000643623
  • ENSP00000495245
  • ENST00000644621
  • ENSP00000495914
  • ENST00000644685
  • ENSP00000496721

Symbol
  • C6orf32
  • DIFF48
  • FAM65B
  • KIAA0386
  • PL48
  • PL48
  • DIFF40
  • DIFF48
  • FAM65B
  • MYONAP
  • C6orf32
  • DFNB104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0