| Tbio | Disheveled-associated activator of morphogenesis 1 |
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity).
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3099 | 1.32232894611871E-11 |
| Duchenne muscular dystrophy | 602 | 1.38837104144704E-7 |
| tuberculosis | 1563 | 1.32017356217125E-6 |
| malignant mesothelioma | 3163 | 9.99339588202752E-6 |
| medulloblastoma, large-cell | 6234 | 3.48899110061694E-5 |
| Pick disease | 1893 | 9.18575365426959E-5 |
| ovarian cancer | 8492 | 1.183300138309E-4 |
| atypical teratoid / rhabdoid tumor | 4369 | 2.6666211444619E-4 |
| acute quadriplegic myopathy | 1157 | 3.15668771580482E-4 |
| sonic hedgehog group medulloblastoma | 1482 | 9.95209121729365E-4 |
| pilocytic astrocytoma | 3086 | 0.00137102164523382 |
| dermatomyositis | 967 | 0.00140108764248812 |
| glioblastoma | 5572 | 0.00140266347165367 |
| osteosarcoma | 7933 | 0.00312347315669056 |
| cutaneous lupus erythematosus | 1056 | 0.00336445076227688 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.0111988119882262 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.0155414365684015 |
| Rheumatoid Arthritis | 1171 | 0.0261667090029741 |
| colon cancer | 1475 | 0.027942048348742 |
| spina bifida | 1064 | 0.0294440173606223 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chondrosarcoma | 24 | 3.267 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| Rheumatoid Arthritis | 1.600 | 0.026 |
| malignant mesothelioma | -1.100 | 0.000 |
| cutaneous lupus erythematosus | -1.200 | 0.003 |
| osteosarcoma | -1.693 | 0.003 |
| atypical teratoid / rhabdoid tumor | -1.500 | 0.000 |
| glioblastoma | -1.400 | 0.001 |
| medulloblastoma, large-cell | -1.100 | 0.000 |
| Duchenne muscular dystrophy | 1.020 | 0.000 |
| acute quadriplegic myopathy | 1.101 | 0.000 |
| tuberculosis | -1.100 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 0.016 |
| intraductal papillary-mucinous carcinoma... | 1.200 | 0.011 |
| colon cancer | -1.500 | 0.028 |
| pilocytic astrocytoma | -1.200 | 0.001 |
| sonic hedgehog group medulloblastoma | 1.400 | 0.001 |
| spina bifida | -1.564 | 0.029 |
| Pick disease | 1.300 | 0.000 |
| Breast cancer | -1.400 | 0.000 |
| ovarian cancer | -2.100 | 0.000 |
| dermatomyositis | 1.200 | 0.001 |
| Species | Source |
|---|---|
| Chimp | OMA Inparanoid |
| Macaque | OMA Inparanoid |
| Mouse | OMA Inparanoid |
| Rat | OMA Inparanoid |
| Dog | OMA Inparanoid |
| Horse | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Pig | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| Zebrafish | OMA Inparanoid |
| PMID | Text |
|---|---|
| 24696301 | Daam1 plays a dual role in the phagocytic uptake of borreliae. |
| 22869791 | A developmentally restricted function of miR-490 and its putative DAAM1 target are associated with exaggerated megakaryocytopoiesis and/or proplatelet formation. |
| 22655072 | Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA. |
| 20927366 | DAAM1 is a formin required for centrosome re-orientation during cell migration. |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 20351293 | DAAM1 regulates endothelial cell growth through MT stabilization in a cell type-selective manner |
| 20223827 | Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs. |
| 18218625 | mDia1 and Daam1 are platelet actin assembly factors having distinct efficiencies, and they are directly regulated by Rho GTPases |
| 18162551 | a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1 |
| 17986009 | Crystal structure of human DAAM1 formin homology 2 domain |
| More... |
MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKH 1 - 70 REAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTA 71 - 140 LRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQ 141 - 210 SLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTA 211 - 280 IMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRF 281 - 350 ELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQ 351 - 420 DPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKM 421 - 490 KEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGG 491 - 560 MLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTE 561 - 630 IDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILL 631 - 700 SRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHY 701 - 770 QQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSL 771 - 840 NKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETEL 841 - 910 EYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFL 911 - 980 QAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRSGEVFDKDL 981 - 1050 SKLKRNRKRITNQMTDSSRERPITKLNF 1051 - 1078 //
| PMID | Year | Title |
|---|---|---|
| 26644512 | 2015 | The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells. |
| 25241761 | 2014 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. |
| 24696301 | 2014 | Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages. |
| 24431302 | 2014 | Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22869791 | 2012 | Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms. |
| 22857009 | 2012 | Deletion of a single-copy DAAM1 gene in congenital heart defect: a case report. |
| 22655072 | 2012 | Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| More... |
