| Tbio | Disheveled-associated activator of morphogenesis 1 |
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity).
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 1.3e-11 |
| Duchenne muscular dystrophy | 601 | 1.4e-07 |
| tuberculosis | 2010 | 1.3e-06 |
| malignant mesothelioma | 3232 | 1.0e-05 |
| medulloblastoma, large-cell | 6241 | 3.5e-05 |
| Pick disease | 1894 | 9.2e-05 |
| ovarian cancer | 8520 | 1.2e-04 |
| acute quadriplegic myopathy | 1158 | 3.2e-04 |
| sonic hedgehog group medulloblastoma | 467 | 1.0e-03 |
| dermatomyositis | 966 | 1.4e-03 |
| glioblastoma | 5792 | 1.4e-03 |
| Astrocytoma, Pilocytic | 3081 | 2.0e-03 |
| osteosarcoma | 7950 | 3.1e-03 |
| cutaneous lupus erythematosus | 1057 | 3.4e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.1e-02 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.3e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.6e-02 |
| Rheumatoid arthritis | 1191 | 2.6e-02 |
| colon cancer | 1478 | 2.8e-02 |
| spina bifida | 1074 | 2.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.101 | 3.2e-04 |
| Astrocytoma, Pilocytic | -1.100 | 2.0e-03 |
| atypical teratoid / rhabdoid tumor | -1.200 | 1.3e-02 |
| Breast cancer | -1.400 | 1.3e-11 |
| colon cancer | -1.500 | 2.8e-02 |
| cutaneous lupus erythematosus | -1.200 | 3.4e-03 |
| dermatomyositis | 1.200 | 1.4e-03 |
| Duchenne muscular dystrophy | 1.020 | 1.4e-07 |
| glioblastoma | -1.400 | 1.4e-03 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 1.6e-02 |
| intraductal papillary-mucinous carcinoma... | 1.200 | 1.1e-02 |
| malignant mesothelioma | -1.100 | 1.0e-05 |
| medulloblastoma, large-cell | -1.100 | 3.5e-05 |
| osteosarcoma | -1.693 | 3.1e-03 |
| ovarian cancer | -2.100 | 1.2e-04 |
| Pick disease | 1.300 | 9.2e-05 |
| Rheumatoid arthritis | 1.600 | 2.6e-02 |
| sonic hedgehog group medulloblastoma | 1.400 | 1.0e-03 |
| spina bifida | -1.564 | 2.9e-02 |
| tuberculosis | -1.100 | 1.3e-06 |
MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKH 1 - 70 REAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTA 71 - 140 LRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQ 141 - 210 SLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTA 211 - 280 IMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRF 281 - 350 ELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQ 351 - 420 DPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKM 421 - 490 KEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGG 491 - 560 MLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTE 561 - 630 IDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILL 631 - 700 SRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHY 701 - 770 QQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSL 771 - 840 NKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETEL 841 - 910 EYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFL 911 - 980 QAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRSGEVFDKDL 981 - 1050 SKLKRNRKRITNQMTDSSRERPITKLNF 1051 - 1078 //
