Tbio NR2E1 Nuclear receptor subfamily 2 group E member 1

Protein Summary

Description

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• Q9Y466
• Q6ZMP8

Gene Name

• NR2E1

Ensembl ID

• ENST00000368983
• ENSP00000357979
• ENSG00000112333
• ENST00000368986
• ENSP00000357982

Symbol

• TLX
• TLL
• TLX
• XTLL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
molecular function	0.9
protein domain	0.73
PubMedID	0.62
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Receptor Subfamily 2 Group E Member 1

Protein / Receptor / Nuclear Receptor Subfamily 2 Group E Member 1

Protein / Nucleic Acid Binding / Nuclear Receptor Subfamily 2 Group E Member 1

Protein / ... / C4 Zinc Finger Nuclear Receptor / Nuclear Receptor Subfamily 2 Group E Member 1

DTO Classes

Protein / Nuclear Receptor / Tailless-like Receptors / Nuclear Receptor Subfamily 2 Group E Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.18   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.18   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0