TBX22
T-box transcription factor TBX22
Protein Summary
Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000373294
- ENSP00000362390
- ENSG00000122145
- ENST00000373296
- ENSP00000362393
- ENST00000619509
- ENSP00000479825
- ENSG00000277800
- ENST00000628957
- ENSP00000487295
- TBOX22
- CPX
- CLPA
- TBXX
- ABERS
- dJ795G23.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.7 | ||
phenotype | 0.57 | ||
biological process | 0.55 | ||
transcription factor | 0.55 | ||
gene perturbation | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.05 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.05 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0