| Tbio | Charged multivesicular body protein 3 |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]
This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 8.5e-16 |
| ovarian cancer | 8520 | 6.6e-09 |
| osteosarcoma | 7950 | 1.9e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.7e-06 |
| medulloblastoma, large-cell | 6241 | 8.4e-05 |
| lung cancer | 4740 | 2.5e-03 |
| Multiple myeloma | 1332 | 6.1e-03 |
| Breast cancer | 3578 | 4.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.300 | 1.7e-06 |
| Breast cancer | 2.700 | 4.3e-02 |
| lung adenocarcinoma | -1.600 | 8.5e-16 |
| lung cancer | -1.200 | 2.5e-03 |
| medulloblastoma, large-cell | -1.200 | 8.4e-05 |
| Multiple myeloma | 1.007 | 6.1e-03 |
| osteosarcoma | 2.180 | 1.9e-07 |
| ovarian cancer | -2.000 | 6.6e-09 |
